Papillary and peripapillary vascular densities and corresponding correlation with peripapillary retinal thicknesses using optical coherence tomography angiography in healthy children and adolescents

• Published in: Scientific reports 2024-03, Vol.14 (1), p.5372-9, Article 5372
• Main Authors: Ghassemi, Fariba, Salari, Farhad, Hatami, Vahid, Mohebbi, Masoumeh, Sabour, Siamak
• Format: Article
• Language: English
• Subjects: 631/378/2613/1786; 692/698/1688/512/2613/1786; Adolescent; Angiography; Child; Children; Cross-Sectional Studies; Female; Humanities and Social Sciences; Humans; Male; Medical imaging; Microvascular Density; multidisciplinary; Optic nerve; Retina; Retina - diagnostic imaging; Science; Science (multidisciplinary); Tomography; Tomography, Optical Coherence; Variance analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-50934-3

To evaluate the peripapillary retinal thickness (PPRT), vascular density (PPVD), and disc vascular density (PVD) and their correlations in normal healthy children using optical coherence tomography angiography (OCTA). This was a cross-sectional study of 70 eyes from 36 normal healthy children aged 6–18 years who performed optic nerve head scans using OCTA. The PPRT included the peripapillary nerve fiber layer (PP-RNFLT), inner retina (PP-IRT), middle retinal thickness, and outer retinal thicknesses. The PP-RNFLT and PP-IRT were not significantly different between males and females. Superior nasal peripapillary RNFLT and IRT were significantly affected by age (ANOVA, P  > 0.05). The PP-IRT and PP-RNFLT were lower in the 7–11 years old group in comparison with the other 3 groups (Post hoc Tukey test, P value  0.05). PPRT was not correlated with PVD, PPVD, superficial and deep retinal vascular densities, and choroidal vascular density. This study demonstrated that PPRT appears to change during growth in childhood. Superior nasal PPRT was affected more in the groups, decreasing from less than 7 years old to 7–11 years old and then back to pre-reduction values after 11 years old.