A Putative Role for Ubiquitin-Proteasome Signaling in Estrogenic Memory Regulation

Sex steroid hormones such as 17β-estradiol (E ) are critical neuromodulators of hippocampal synaptic plasticity and hippocampus-dependent memory in both males and females. However, the mechanisms through which E regulates memory formation in both sexes remain unclear. Research to date suggests that...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2022-01, Vol.15, p.807215-807215
Main Authors: Beamish, Sarah B, Frick, Karyn M
Format: Article
Language:English
Subjects:
17β-Estradiol
Behavioral Neuroscience
Cognition
Degradation
Estrogens
Females
Hippocampal plasticity
Hippocampus
Hormones
Kinases
Memory
Morphology
Neuromodulation
Neurons
Polymerization
proteasome
Proteasomes
Protein composition
protein degradation
Protein synthesis
Proteins
Sexes
Signal transduction
Steroid hormones
Steroids
Synaptic plasticity
Ubiquitin
Xenoestrogens
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sex steroid hormones such as 17β-estradiol (E ) are critical neuromodulators of hippocampal synaptic plasticity and hippocampus-dependent memory in both males and females. However, the mechanisms through which E regulates memory formation in both sexes remain unclear. Research to date suggests that E regulates hippocampus-dependent memory by activating numerous cell-signaling cascades to promote the synthesis of proteins that support structural changes at hippocampal synapses. However, this work has largely overlooked the equally important contributions of protein degradation mediated by the ubiquitin proteasome system (UPS) in remodeling the synapse. Despite being critically implicated in synaptic plasticity and successful formation of long-term memories, it remains unclear whether protein degradation mediated by the UPS is necessary for E to exert its beneficial effects on hippocampal plasticity and memory formation. The present article provides an overview of the receptor and signaling mechanisms so far identified as critical for regulating hippocampal E and UPS function in males and females, with a particular emphasis on the ways in which these mechanisms overlap to support structural integrity and protein composition of hippocampal synapses. We argue that the high degree of correspondence between E and UPS activity warrants additional study to examine the contributions of ubiquitin-mediated protein degradation in regulating the effects of sex steroid hormones on cognition.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2021.807215