A Nogo-Like Signaling Perspective from Birth to Adulthood and in Old Age: Brain Expression Patterns of Ligands, Receptors and Modulators

An appropriate strength of Nogo-like signaling is important to maintain synaptic homeostasis in the CNS. Disturbances have been associated with schizophrenia, MS and other diseases. Blocking Nogo-like signaling may improve recovery after spinal cord injury, stroke and traumatic brain injury. To unde...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in molecular neuroscience 2018-02, Vol.11, p.42-42
Main Authors: Smedfors, Gabriella, Olson, Lars, Karlsson, Tobias E
Format: Article
Language:English
Subjects:
Aging
Amygdala
Birth
Cortex
development
Gene regulation
Genes
Glycoproteins
Hippocampus
Homeostasis
Hybridization
LGI1 protein
Ligands
Lingo-1
Mental disorders
Nervous system
Neuroscience
NgR1
Nogo protein
Nogo-A
Olfactomedin
Oligodendrocyte-myelin glycoprotein
OMgp
Proteins
Schizophrenia
Spinal cord injuries
Transcription
Traumatic brain injury
Troy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An appropriate strength of Nogo-like signaling is important to maintain synaptic homeostasis in the CNS. Disturbances have been associated with schizophrenia, MS and other diseases. Blocking Nogo-like signaling may improve recovery after spinal cord injury, stroke and traumatic brain injury. To understand the interacting roles of an increasing number of ligands, receptors and modulators engaged in Nogo-like signaling, the transcriptional activity of these genes in the same brain areas from birth to old age in the normal brain is needed. Thus, we have quantitatively mapped the innate expression of 11 important genes engaged in Nogo-like signaling. Using hybridization, we located and measured the amount of mRNA encoding Nogo-A, OMgp, NgR1, NgR2, NgR3, Lingo-1, Troy, Olfactomedin, LgI1, ADAM22, and MAG, in 18 different brain areas at six different ages (P0, 1, 2, 4, 14, and 104 weeks). We show gene- and area-specific activities and how the genes undergo dynamic regulation during postnatal development and become stable during adulthood. Hippocampal areas underwent the largest changes over time. We only found differences between individual cortical areas in Troy and MAG. Subcortical areas presented the largest inter-regional differences; lateral and basolateral amygdala had markedly higher expression than other subcortical areas. The widespread differences and unique expression patterns of the different genes involved in Nogo-like signaling suggest that the functional complexes could look vastly different in different areas.
ISSN:1662-5099
1662-5099
DOI:10.3389/fnmol.2018.00042