The Prospect and Challenges to the Flow of Liquid Biopsy in Africa

Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African con...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-08, Vol.8 (8), p.862
Main Authors: Temilola, Dada Oluwaseyi, Wium, Martha, Coulidiati, Tangbadioa Herve, Adeola, Henry Ademola, Carbone, Giuseppina Maria, Catapano, Carlo Vittorio, Zerbini, Luiz Fernando
Format: Article
Language:English
Subjects:
Africa
Biomarkers
Biomarkers, Tumor - analysis
Biopsy
Breast cancer
Cancer
Cancer therapies
cell-free DNA
Chronic obstructive pulmonary disease
circulating RNA
circulating tumor cell
Colorectal cancer
Diagnosis
Disease
Epigenetics
FDA approval
Genetic factors
Humans
Liquid Biopsy
Lung cancer
Medical diagnosis
Medical prognosis
Metastasis
Mortality
Neoplasms - diagnosis
Neoplastic Cells, Circulating - pathology
non-invasive
Pathogens
Patients
Population
Population genetics
Prostate cancer
Proteins
Review
Tumor cells
Tumors
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Summary:Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for surgical biopsies. To apply liquid biopsy technologies in the African setting, the influence of environmental and population genetic factors must be known. In this review, we discuss the use of circulating tumor cells, cell-free nucleic acids, extracellular vesicles, protein, and other biomolecules in liquid biopsy technology for cancer management with special focus on African studies. We discussed the prospect, barriers, and other aspects that pose challenges to the use of liquid biopsy in the African continent.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8080862