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The Prospect and Challenges to the Flow of Liquid Biopsy in Africa

Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African con...

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Published in:	Cells (Basel, Switzerland) Switzerland), 2019-08, Vol.8 (8), p.862
Main Authors:	Temilola, Dada Oluwaseyi, Wium, Martha, Coulidiati, Tangbadioa Herve, Adeola, Henry Ademola, Carbone, Giuseppina Maria, Catapano, Carlo Vittorio, Zerbini, Luiz Fernando
Format:	Article
Language:	English
Subjects:	Africa Biomarkers Biomarkers, Tumor - analysis Biopsy Breast cancer Cancer Cancer therapies cell-free DNA Chronic obstructive pulmonary disease circulating RNA circulating tumor cell Colorectal cancer Diagnosis Disease Epigenetics FDA approval Genetic factors Humans Liquid Biopsy Lung cancer Medical diagnosis Medical prognosis Metastasis Mortality Neoplasms - diagnosis Neoplastic Cells, Circulating - pathology non-invasive Pathogens Patients Population Population genetics Prostate cancer Proteins Review Tumor cells Tumors
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creator	Temilola, Dada Oluwaseyi Wium, Martha Coulidiati, Tangbadioa Herve Adeola, Henry Ademola Carbone, Giuseppina Maria Catapano, Carlo Vittorio Zerbini, Luiz Fernando
description	Liquid biopsy technologies have the potential to transform cancer patient management as it offers non-invasive diagnosis and real-time monitoring of disease progression and treatment responses. The use of liquid biopsy for non-invasive cancer diagnosis can have pivotal importance for the African continent where access to medical infrastructures is limited, as it eliminates the need for surgical biopsies. To apply liquid biopsy technologies in the African setting, the influence of environmental and population genetic factors must be known. In this review, we discuss the use of circulating tumor cells, cell-free nucleic acids, extracellular vesicles, protein, and other biomolecules in liquid biopsy technology for cancer management with special focus on African studies. We discussed the prospect, barriers, and other aspects that pose challenges to the use of liquid biopsy in the African continent.
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subjects	Africa Biomarkers Biomarkers, Tumor - analysis Biopsy Breast cancer Cancer Cancer therapies cell-free DNA Chronic obstructive pulmonary disease circulating RNA circulating tumor cell Colorectal cancer Diagnosis Disease Epigenetics FDA approval Genetic factors Humans Liquid Biopsy Lung cancer Medical diagnosis Medical prognosis Metastasis Mortality Neoplasms - diagnosis Neoplastic Cells, Circulating - pathology non-invasive Pathogens Patients Population Population genetics Prostate cancer Proteins Review Tumor cells Tumors
title	The Prospect and Challenges to the Flow of Liquid Biopsy in Africa
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