RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae

RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein comp...

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Bibliographic Details
Published in:Genetics and molecular biology 2017-01, Vol.40 (1), p.22-30
Main Authors: Oliveira, Camila, Faoro, Helisson, Alves, Lysangela Ronalte, Goldenberg, Samuel
Format: Article
Language:English
Subjects:
BIOCHEMISTRY & MOLECULAR BIOLOGY
gene expression regulation
GENETICS & HEREDITY
RNA-binding proteins
Saccharomyces cerevisiae
Special Series of - 60 Years of The Brazilian Society of Genetics
Trypanosoma cruzi
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Summary:RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast.
ISSN:1415-4757
1678-4685
1415-4757
1678-4685
DOI:10.1590/1678-4685-GMB-2016-0258