Vaccination-Route-Dependent Adjuvanticity of Antigen-Carrying Nanoparticles for Enhanced Vaccine Efficacy

Vaccination-route-dependent adjuvanticity was identified as being associated with the specific features of antigen-carrying nanoparticles (NPs) in the present work. Here, we demonstrated that the mechanical properties and the decomposability of NP adjuvants play key roles in determining the antigen...

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Bibliographic Details
Published in:Vaccines (Basel) 2024-01, Vol.12 (2), p.125
Main Authors: Song, Chaojun, Hu, Jinwei, Liu, Yutao, Tian, Yi, Zhu, Yupu, Xi, Jiayue, Cui, Minxuan, Wang, Xiaolei, Zhang, Bao-Zhong, Fan, Li, Li, Quan
Format: Article
Language:English
Subjects:
Acids
Adjuvanticity
Adjuvants
Aluminum
Antibodies
Antigens
decomposability
Decomposition
Dosage and administration
Drug resistance
Effectiveness
Enzymes
Fourier transforms
Health aspects
Immune response (cell-mediated)
Immune response (humoral)
Immune system
Immunological adjuvants
Mechanical properties
mechanical property
nano-vaccine
nanoparticle adjuvant
Nanoparticles
Polymers
Polyvinyl alcohol
Prevention
Proteins
Staphylococcus aureus infections
Survival
Testing
vaccination route
Vaccine efficacy
Vaccines
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Summary:Vaccination-route-dependent adjuvanticity was identified as being associated with the specific features of antigen-carrying nanoparticles (NPs) in the present work. Here, we demonstrated that the mechanical properties and the decomposability of NP adjuvants play key roles in determining the antigen accessibility and thus the overall vaccine efficacy in the immune system when different vaccination routes were employed. We showed that soft nano-vaccines were associated with more efficient antigen uptake when administering subcutaneous (S.C.) vaccination, while the slow decomposition of hard nano-vaccines promoted antigen uptake when intravenous (I.V.) vaccination was employed. In comparison to the clinically used aluminum (Alum) adjuvant, the NP adjuvants were found to stimulate both humoral and cellular immune responses efficiently, irrespective of the vaccination route. For vaccination via S.C. and I.V. alike, the NP-based vaccines show excellent protection for mice from ( ) infection, and their survival rates are 100% after lethal challenge, being much superior to the clinically used Alum adjuvant.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines12020125