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The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach
Puerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase representation of this group in genomic studies of AD, we developed a multisource ascertainment approach to enroll AD patients, and their family member...
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Published in: | Frontiers in genetics 2019-06, Vol.10, p.538-538 |
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creator | Feliciano-Astacio, Briseida E Celis, Katrina Ramos, Jairo Rajabli, Farid Adams, Larry Deon Rodriguez, Alejandra Rodriguez, Vanessa Bussies, Parker L Sierra, Carolina Manrique, Patricia Mena, Pedro R Grana, Antonella Prough, Michael Hamilton-Nelson, Kara L Feliciano, Nereida Chinea, Angel Acosta, Heriberto McCauley, Jacob L Vance, Jeffery M Beecham, Gary W Pericak-Vance, Margaret A Cuccaro, Michael L |
description | Puerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase representation of this group in genomic studies of AD, we developed a multisource ascertainment approach to enroll AD patients, and their family members living in Puerto Rico (PR) as part of the Alzheimer's Disease Sequencing Project (ADSP), an international effort to advance broader personalized/precision medicine initiatives for AD across all populations.
The Puerto Rico Alzheimer Disease Initiative (PRADI) multisource ascertainment approach was developed to recruit and enroll Puerto Rican adults aged 50 years and older for a genetic research study of AD, including individuals with cognitive decline (AD, mild cognitive impairment), their similarly, aged family members, and cognitively healthy unrelated individuals age 50 and up. Emphasizing identification and relationship building with key stakeholders, we conducted ascertainment across the island. In addition to reporting on PRADI ascertainment, we detail admixture analysis for our cohort by region, group differences in age of onset, cognitive level by region, and ascertainment source.
We report on 674 individuals who met standard eligibility criteria [282 AD-affected participants (42% of the sample), 115 individuals with mild cognitive impairment (MCI) (17% of the sample), and 277 cognitively healthy individuals (41% of the sample)]. There are 43 possible multiplex families (10 families with 4 or more AD-affected members and 3 families with 3 AD-affected members). Most individuals in our cohort were ascertained from the Metro, Bayamón, and Caguas health regions. Across health regions, we found differences in ancestral backgrounds, and select clinical traits.
The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers. Preliminary results provide important information about our cohort that will be useful as we move forward with ascertainment. We expect that results from the PRADI study will lead to a better understanding of genetic risk for AD among this population. |
doi_str_mv | 10.3389/fgene.2019.00538 |
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The Puerto Rico Alzheimer Disease Initiative (PRADI) multisource ascertainment approach was developed to recruit and enroll Puerto Rican adults aged 50 years and older for a genetic research study of AD, including individuals with cognitive decline (AD, mild cognitive impairment), their similarly, aged family members, and cognitively healthy unrelated individuals age 50 and up. Emphasizing identification and relationship building with key stakeholders, we conducted ascertainment across the island. In addition to reporting on PRADI ascertainment, we detail admixture analysis for our cohort by region, group differences in age of onset, cognitive level by region, and ascertainment source.
We report on 674 individuals who met standard eligibility criteria [282 AD-affected participants (42% of the sample), 115 individuals with mild cognitive impairment (MCI) (17% of the sample), and 277 cognitively healthy individuals (41% of the sample)]. There are 43 possible multiplex families (10 families with 4 or more AD-affected members and 3 families with 3 AD-affected members). Most individuals in our cohort were ascertained from the Metro, Bayamón, and Caguas health regions. Across health regions, we found differences in ancestral backgrounds, and select clinical traits.
The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers. Preliminary results provide important information about our cohort that will be useful as we move forward with ascertainment. We expect that results from the PRADI study will lead to a better understanding of genetic risk for AD among this population.</description><identifier>ISSN: 1664-8021</identifier><identifier>EISSN: 1664-8021</identifier><identifier>DOI: 10.3389/fgene.2019.00538</identifier><identifier>PMID: 31275353</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>ADSP ; Alzheimer disease ; ascertainment ; community resources ; Genetics ; PRADI</subject><ispartof>Frontiers in genetics, 2019-06, Vol.10, p.538-538</ispartof><rights>Copyright © 2019 Feliciano-Astacio, Celis, Ramos, Rajabli, Adams, Rodriguez, Rodriguez, Bussies, Sierra, Manrique, Mena, Grana, Prough, Hamilton-Nelson, Feliciano, Chinea, Acosta, McCauley, Vance, Beecham, Pericak-Vance and Cuccaro. 2019 Feliciano-Astacio, Celis, Ramos, Rajabli, Adams, Rodriguez, Rodriguez, Bussies, Sierra, Manrique, Mena, Grana, Prough, Hamilton-Nelson, Feliciano, Chinea, Acosta, McCauley, Vance, Beecham, Pericak-Vance and Cuccaro</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-79f0886b8af0d8ee2609823ad64a65f065e0cb33e49f11c48dc4995ac6247d583</citedby><cites>FETCH-LOGICAL-c462t-79f0886b8af0d8ee2609823ad64a65f065e0cb33e49f11c48dc4995ac6247d583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593074/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593074/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31275353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feliciano-Astacio, Briseida E</creatorcontrib><creatorcontrib>Celis, Katrina</creatorcontrib><creatorcontrib>Ramos, Jairo</creatorcontrib><creatorcontrib>Rajabli, Farid</creatorcontrib><creatorcontrib>Adams, Larry Deon</creatorcontrib><creatorcontrib>Rodriguez, Alejandra</creatorcontrib><creatorcontrib>Rodriguez, Vanessa</creatorcontrib><creatorcontrib>Bussies, Parker L</creatorcontrib><creatorcontrib>Sierra, Carolina</creatorcontrib><creatorcontrib>Manrique, Patricia</creatorcontrib><creatorcontrib>Mena, Pedro R</creatorcontrib><creatorcontrib>Grana, Antonella</creatorcontrib><creatorcontrib>Prough, Michael</creatorcontrib><creatorcontrib>Hamilton-Nelson, Kara L</creatorcontrib><creatorcontrib>Feliciano, Nereida</creatorcontrib><creatorcontrib>Chinea, Angel</creatorcontrib><creatorcontrib>Acosta, Heriberto</creatorcontrib><creatorcontrib>McCauley, Jacob L</creatorcontrib><creatorcontrib>Vance, Jeffery M</creatorcontrib><creatorcontrib>Beecham, Gary W</creatorcontrib><creatorcontrib>Pericak-Vance, Margaret A</creatorcontrib><creatorcontrib>Cuccaro, Michael L</creatorcontrib><title>The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach</title><title>Frontiers in genetics</title><addtitle>Front Genet</addtitle><description>Puerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase representation of this group in genomic studies of AD, we developed a multisource ascertainment approach to enroll AD patients, and their family members living in Puerto Rico (PR) as part of the Alzheimer's Disease Sequencing Project (ADSP), an international effort to advance broader personalized/precision medicine initiatives for AD across all populations.
The Puerto Rico Alzheimer Disease Initiative (PRADI) multisource ascertainment approach was developed to recruit and enroll Puerto Rican adults aged 50 years and older for a genetic research study of AD, including individuals with cognitive decline (AD, mild cognitive impairment), their similarly, aged family members, and cognitively healthy unrelated individuals age 50 and up. Emphasizing identification and relationship building with key stakeholders, we conducted ascertainment across the island. In addition to reporting on PRADI ascertainment, we detail admixture analysis for our cohort by region, group differences in age of onset, cognitive level by region, and ascertainment source.
We report on 674 individuals who met standard eligibility criteria [282 AD-affected participants (42% of the sample), 115 individuals with mild cognitive impairment (MCI) (17% of the sample), and 277 cognitively healthy individuals (41% of the sample)]. There are 43 possible multiplex families (10 families with 4 or more AD-affected members and 3 families with 3 AD-affected members). Most individuals in our cohort were ascertained from the Metro, Bayamón, and Caguas health regions. Across health regions, we found differences in ancestral backgrounds, and select clinical traits.
The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers. Preliminary results provide important information about our cohort that will be useful as we move forward with ascertainment. We expect that results from the PRADI study will lead to a better understanding of genetic risk for AD among this population.</description><subject>ADSP</subject><subject>Alzheimer disease</subject><subject>ascertainment</subject><subject>community resources</subject><subject>Genetics</subject><subject>PRADI</subject><issn>1664-8021</issn><issn>1664-8021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1v3CAQQK2qVROlufdUcUwPuwUGWOihkpX0Y6VUjaL00gvCeLxLZJst2JHaX1-ym0YJFxAz84bhVdVbRpcA2nzoNjjiklNmlpRK0C-qY6aUWGjK2csn56PqNOdbWpYwACBeV0fA-EqChOPq180WydWMaYrkOvhI6v7vFsOAiVyEjC4jWY9hCm4Kd0jOrq7ri_X7j6Qm3-d-CjnOySOpsy8AF8YBx4nUu12Kzm_fVK8612c8fdhPqp9fPt-cf1tc_vi6Pq8vF14oPi1WpqNaq0a7jrYakStqNAfXKuGU7KiSSH0DgMJ0jHmhWy-Mkc4rLlat1HBSrQ_cNrpbu0thcOmPjS7Y_UVMG-vSFHyPVjXgwbTAWugEBWcAHROmcXQljEZeWJ8OrN3cDNj6Mk9y_TPo88gYtnYT76ySBgqkAM4eACn-njFPdgjld_rejRjnbDmXwDWTTJZUekj1KeacsHtsw6i9N2z3hu29Ybs3XErePX3eY8F_n_APAu2hpw</recordid><startdate>20190619</startdate><enddate>20190619</enddate><creator>Feliciano-Astacio, Briseida E</creator><creator>Celis, Katrina</creator><creator>Ramos, Jairo</creator><creator>Rajabli, Farid</creator><creator>Adams, Larry Deon</creator><creator>Rodriguez, Alejandra</creator><creator>Rodriguez, Vanessa</creator><creator>Bussies, Parker L</creator><creator>Sierra, Carolina</creator><creator>Manrique, Patricia</creator><creator>Mena, Pedro R</creator><creator>Grana, Antonella</creator><creator>Prough, Michael</creator><creator>Hamilton-Nelson, Kara L</creator><creator>Feliciano, Nereida</creator><creator>Chinea, Angel</creator><creator>Acosta, Heriberto</creator><creator>McCauley, Jacob L</creator><creator>Vance, Jeffery M</creator><creator>Beecham, Gary W</creator><creator>Pericak-Vance, Margaret A</creator><creator>Cuccaro, Michael L</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190619</creationdate><title>The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach</title><author>Feliciano-Astacio, Briseida E ; Celis, Katrina ; Ramos, Jairo ; Rajabli, Farid ; Adams, Larry Deon ; Rodriguez, Alejandra ; Rodriguez, Vanessa ; Bussies, Parker L ; Sierra, Carolina ; Manrique, Patricia ; Mena, Pedro R ; Grana, Antonella ; Prough, Michael ; Hamilton-Nelson, Kara L ; Feliciano, Nereida ; Chinea, Angel ; Acosta, Heriberto ; McCauley, Jacob L ; Vance, Jeffery M ; Beecham, Gary W ; Pericak-Vance, Margaret A ; Cuccaro, Michael L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-79f0886b8af0d8ee2609823ad64a65f065e0cb33e49f11c48dc4995ac6247d583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>ADSP</topic><topic>Alzheimer disease</topic><topic>ascertainment</topic><topic>community resources</topic><topic>Genetics</topic><topic>PRADI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feliciano-Astacio, Briseida E</creatorcontrib><creatorcontrib>Celis, Katrina</creatorcontrib><creatorcontrib>Ramos, Jairo</creatorcontrib><creatorcontrib>Rajabli, Farid</creatorcontrib><creatorcontrib>Adams, Larry Deon</creatorcontrib><creatorcontrib>Rodriguez, Alejandra</creatorcontrib><creatorcontrib>Rodriguez, Vanessa</creatorcontrib><creatorcontrib>Bussies, Parker L</creatorcontrib><creatorcontrib>Sierra, Carolina</creatorcontrib><creatorcontrib>Manrique, Patricia</creatorcontrib><creatorcontrib>Mena, Pedro R</creatorcontrib><creatorcontrib>Grana, Antonella</creatorcontrib><creatorcontrib>Prough, Michael</creatorcontrib><creatorcontrib>Hamilton-Nelson, Kara L</creatorcontrib><creatorcontrib>Feliciano, Nereida</creatorcontrib><creatorcontrib>Chinea, Angel</creatorcontrib><creatorcontrib>Acosta, Heriberto</creatorcontrib><creatorcontrib>McCauley, Jacob L</creatorcontrib><creatorcontrib>Vance, Jeffery M</creatorcontrib><creatorcontrib>Beecham, Gary W</creatorcontrib><creatorcontrib>Pericak-Vance, Margaret A</creatorcontrib><creatorcontrib>Cuccaro, Michael L</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feliciano-Astacio, Briseida E</au><au>Celis, Katrina</au><au>Ramos, Jairo</au><au>Rajabli, Farid</au><au>Adams, Larry Deon</au><au>Rodriguez, Alejandra</au><au>Rodriguez, Vanessa</au><au>Bussies, Parker L</au><au>Sierra, Carolina</au><au>Manrique, Patricia</au><au>Mena, Pedro R</au><au>Grana, Antonella</au><au>Prough, Michael</au><au>Hamilton-Nelson, Kara L</au><au>Feliciano, Nereida</au><au>Chinea, Angel</au><au>Acosta, Heriberto</au><au>McCauley, Jacob L</au><au>Vance, Jeffery M</au><au>Beecham, Gary W</au><au>Pericak-Vance, Margaret A</au><au>Cuccaro, Michael L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach</atitle><jtitle>Frontiers in genetics</jtitle><addtitle>Front Genet</addtitle><date>2019-06-19</date><risdate>2019</risdate><volume>10</volume><spage>538</spage><epage>538</epage><pages>538-538</pages><issn>1664-8021</issn><eissn>1664-8021</eissn><abstract>Puerto Ricans, the second largest Latino group in the continental US, are underrepresented in genomic studies of Alzheimer disease (AD). To increase representation of this group in genomic studies of AD, we developed a multisource ascertainment approach to enroll AD patients, and their family members living in Puerto Rico (PR) as part of the Alzheimer's Disease Sequencing Project (ADSP), an international effort to advance broader personalized/precision medicine initiatives for AD across all populations.
The Puerto Rico Alzheimer Disease Initiative (PRADI) multisource ascertainment approach was developed to recruit and enroll Puerto Rican adults aged 50 years and older for a genetic research study of AD, including individuals with cognitive decline (AD, mild cognitive impairment), their similarly, aged family members, and cognitively healthy unrelated individuals age 50 and up. Emphasizing identification and relationship building with key stakeholders, we conducted ascertainment across the island. In addition to reporting on PRADI ascertainment, we detail admixture analysis for our cohort by region, group differences in age of onset, cognitive level by region, and ascertainment source.
We report on 674 individuals who met standard eligibility criteria [282 AD-affected participants (42% of the sample), 115 individuals with mild cognitive impairment (MCI) (17% of the sample), and 277 cognitively healthy individuals (41% of the sample)]. There are 43 possible multiplex families (10 families with 4 or more AD-affected members and 3 families with 3 AD-affected members). Most individuals in our cohort were ascertained from the Metro, Bayamón, and Caguas health regions. Across health regions, we found differences in ancestral backgrounds, and select clinical traits.
The multisource ascertainment approach used in the PRADI study highlights the importance of enlisting a broad range of community resources and providers. Preliminary results provide important information about our cohort that will be useful as we move forward with ascertainment. We expect that results from the PRADI study will lead to a better understanding of genetic risk for AD among this population.</abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>31275353</pmid><doi>10.3389/fgene.2019.00538</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | ADSP Alzheimer disease ascertainment community resources Genetics PRADI |
title | The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach |
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