Novel Macrolactams from a Deep-Sea-Derived Streptomyces Species

Four polyene macrolactams including the previously reported niizalactam C ( ), and three new ones, streptolactams A-C ( - ) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep...

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Bibliographic Details
Published in:Marine drugs 2020-12, Vol.19 (1), p.13
Main Authors: Wang, Pei, Wang, Dongyang, Zhang, Rongxin, Wang, Yi, Kong, Fandong, Fu, Peng, Zhu, Weiming
Format: Article
Language:English
Subjects:
abiotic formation
Antifungal activity
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Bioactive compounds
Candida albicans - drug effects
Candida albicans - growth & development
Cell Line, Tumor
Chemical reactions
Cytotoxicity
Deep sea
Deep sea environments
Deep water
Deep-Sea-Derived Streptomyces
Fermentation
Fungicides
Geologic Sediments - microbiology
Humans
Lactams, Macrocyclic - isolation & purification
Lactams, Macrocyclic - pharmacology
macrolactam
Molecular Structure
natural product
Natural products
Streptomyces
Streptomyces - metabolism
Structure-Activity Relationship
X-ray diffraction
X-ray diffraction analysis
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Summary:Four polyene macrolactams including the previously reported niizalactam C ( ), and three new ones, streptolactams A-C ( - ) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds and from compound were confirmed by a series of chemical reactions under heat and light conditions. Compounds and showed a selective antifungal activity against ATCC 10231.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19010013