Femtosecond Laser Patterning of the Biopolymer Chitosan for Biofilm Formation

Controlling microbial growth is crucial for many biomedical, pharmaceutical and food industry applications. In this paper, we used a femtosecond laser to microstructure the surface of chitosan, a biocompatible polymer that has been explored for applications ranging from antimicrobial action to drug...

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Bibliographic Details
Published in:International journal of molecular sciences 2016-08, Vol.17 (8), p.1243-1243
Main Authors: Estevam-Alves, Regina, Ferreira, Paulo Henrique Dias, Coatrini, Andrey C, Oliveira, Osvaldo N, Fontana, Carla Raquel, Mendonca, Cleber Renato
Format: Article
Language:English
Subjects:
Bacteria
Bacterial Adhesion - drug effects
bacterial growth
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biofilms
Biofilms - drug effects
Biopolymers - chemistry
Biopolymers - pharmacology
chitosan
Chitosan - chemistry
Chitosan - pharmacology
fs-laser micromachining
Hydrophobic and Hydrophilic Interactions
Lasers
micropatterning
Microscopy, Atomic Force
Staphylococcus
Staphylococcus aureus - drug effects
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Summary:Controlling microbial growth is crucial for many biomedical, pharmaceutical and food industry applications. In this paper, we used a femtosecond laser to microstructure the surface of chitosan, a biocompatible polymer that has been explored for applications ranging from antimicrobial action to drug delivery. The influence of energy density on the features produced on chitosan was investigated by optical and atomic force microscopies. An increase in the hydrophilic character of the chitosan surface was attained upon laser micromachining. Patterned chitosan films were used to observe Staphylococcus aureus (ATCC 25923) biofilm formation, revealing an increase in the biofilm formation in the structured regions. Our results indicate that fs-laser micromachining is an attractive option to pattern biocompatible surfaces, and to investigate basic aspects of the relationship between surface topography and bacterial adhesion.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms17081243