Association of genetic polymorphisms related to Johne's disease with estimated breeding values of Holstein sires for milk ELISA test scores

Johne's disease (JD) is a chronic intestinal inflammatory disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection in ruminants. Since there are currently no effective vaccine or treatment options available to control JD, genetic selection may be an alternative strategy to...

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Bibliographic Details
Published in:BMC veterinary research 2020-05, Vol.16 (1), p.165-165, Article 165
Main Authors: Mallikarjunappa, Sanjay, Schenkel, Flavio S, Brito, Luiz F, Bissonnette, Nathalie, Miglior, Filippo, Chesnais, Jacques, Lohuis, Michael, Meade, Kieran G, Karrow, Niel A
Format: Article
Language:English
Subjects:
Analysis
Animals
Antibodies
Bos taurus
Breeding
Care and treatment
Cattle
Cattle - genetics
Cattle Diseases - genetics
Cattle Diseases - microbiology
Chromosomes
Chronic infection
Dairy industry
Disease Resistance - genetics
Enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - veterinary
Feces
Genetic research
Genome-Wide Association Study - veterinary
Genomes
Genomics
Gram-positive bacteria
Health aspects
Identification
Infection
Infections
Inflammatory diseases
Intestine
Johne’s disease
Male
Medical research
Milk
Milk - chemistry
Mycobacterium avium paratuberculosis
Mycobacterium avium subsp. paratuberculosis
Paratuberculosis
Paratuberculosis - genetics
Polymorphism, Single Nucleotide - genetics
Regression analysis
Single nucleotide polymorphisms
Single-nucleotide polymorphism
SNP validation
Studies
Vaccines
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Summary:Johne's disease (JD) is a chronic intestinal inflammatory disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection in ruminants. Since there are currently no effective vaccine or treatment options available to control JD, genetic selection may be an alternative strategy to enhance JD resistance. Numerous Single Nucleotide Polymorphisms (SNPs) have been reported to be associated with MAP infection status based on published genome-wide association and candidate gene studies. The main objective of this study was to validate these SNPs that were previously identified to be associated with JD by testing their effect on Holstein bulls' estimated breeding values (EBVs) for milk ELISA test scores, an indirect indicator of MAP infection status in cattle. Three SNPs, rs41810662, rs41617133 and rs110225854, located on Bos taurus autosomes (BTA) 16, 23 and 26, respectively, were confirmed as significantly associated with Holstein bulls' EBVs for milk ELISA test score (FDR 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-020-02381-9