Visual Function after Implantation of Diffractive Extended Depth-of-Focus Intraocular Lenses in Eyes with Primary Open-Angle Glaucoma

• Published in: Ophthalmology and therapy 2023-12, Vol.12 (6), p.3099-3108
• Main Authors: Bissen-Miyajima, Hiroko, Ota, Yuka, Taira, Yoko, Takemura, Ryo, Minami, Keiichiro
• Format: Article
• Language: English
• Subjects: Contrast sensitivity; Extended depth-of-focus intraocular lens; Internal Medicine; Medicine; Medicine & Public Health; Non-inferiority; Ophthalmology; Original Research; Primary open-angle glaucoma; Visual field; Visual function
• ISSN: 2193-8245; 2193-6528
• DOI: 10.1007/s40123-023-00801-1

Introduction The aim of this prospective study was to compare the visual functions of extended depth-of-focus intraocular lenses (EDOF IOLs) and monofocal IOLs in eyes with mild to moderate primary open-angle glaucoma (POAG). Methods Cataractous eyes with POAG controlled using medical treatments, no central visual field defects, and mean deviation (MD) values of −10 dB or better on the 30–2 test grid of the Swedish Interactive Threshold Algorithm standard program were included. Twenty-two eyes of 22 patients received EDOF IOLs (ZXR00V and ZXV150-375; J&J), whereas 24 eyes of 24 patients received monofocal IOLs (ZCB00V and ZCV150-375; J&J). MD values, corrected distance visual acuity (CDVA), and photopic contrast sensitivity were measured at 3 months after surgery. Noninferiority of CDVA and contrast sensitivity in eyes with EDOF IOLs to eyes with monofocal IOLs were examined. Results The postoperative mean MDs of eyes with EDOF and monofocal IOLs were −2.76 dB and −4.21 dB with no significant difference. The CDVA of eyes with EDOF IOLs was noninferior to that of eyes with monofocal IOLs ( P  = 0.02). There were no inferiority in contrast sensitivity at any spatial frequency ( P