Genome-wide piggyBac transposon mediated screening reveals genes related to reprogramming

iPSCs are typically derived using four transcription factors Oct4 （also known as Pou5f1）, Klf4, Sox2 and c-Myc （OKSM） （Takahashi and Yamanaka, 2006）. Major directions in this field are focused on understanding the reprogramming mechanism, optimizing reprogramming methods to improve iPS cell （iPSC） q...

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Bibliographic Details
Published in:Protein & cell 2017-02, Vol.8 (2), p.134-139
Main Authors: Zhang, Xi, Wei, Xinglin, Wu, Yuanyuan, Wang, Yuzhe, Tan, Cheng, Hu, Xiaoxiang, Li, Ning, Capecchi, Mario R., Wu, Sen
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
c-Myc
Cell Biology
Developmental Biology
Human Genetics
Letter
Life Sciences
Protein Science
Stem Cells
介导
全基因组
多能干细胞
相关基因
筛查
编程机制
转座子
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Summary:iPSCs are typically derived using four transcription factors Oct4 （also known as Pou5f1）, Klf4, Sox2 and c-Myc （OKSM） （Takahashi and Yamanaka, 2006）. Major directions in this field are focused on understanding the reprogramming mechanism, optimizing reprogramming methods to improve iPS cell （iPSC） quality, and applications of the cells for regenerative medicine.
ISSN:1674-800X
1674-8018
DOI:10.1007/s13238-016-0332-z