Snapshot into the Type-2-Diabetes-Associated Microbiome of a Romanian Cohort

The prevalence of type 2 diabetes mellitus (T2D) is alarmingly increasing worldwide, urgently calling for a better understanding of the underlying mechanisms in order to step up prevention and improve therapeutic approaches. It is becoming evident that the gut microbiota seem to have an endless capa...

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Published in:International journal of molecular sciences 2022-11, Vol.23 (23), p.15023
Main Authors: Gradisteanu Pircalabioru, Gratiela, Chifiriuc, Mariana-Carmen, Picu, Ariana, Petcu, Laura Madalina, Trandafir, Maria, Savu, Octavian
Format: Article
Language:English
Subjects:
Bacteroidetes
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Feces
Gastrointestinal Microbiome
Glucose
Humans
Hypertension
Insulin
Intestinal microflora
metabolic disease
Metabolism
Metabolites
Metformin
Metformin - therapeutic use
microbiome
Microbiomes
Microbiota
Microorganisms
Next-generation sequencing
Patients
Taxonomy
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Summary:The prevalence of type 2 diabetes mellitus (T2D) is alarmingly increasing worldwide, urgently calling for a better understanding of the underlying mechanisms in order to step up prevention and improve therapeutic approaches. It is becoming evident that the gut microbiota seem to have an endless capacity to impact T2D. In this study, we profile the gut microbiome patterns in T2D patients from Romania, by using quantitative Real-Time PCR and next generation sequencing. We enrolled a total of 150 individuals (105 T2D patients, 50 of them without metformin treatment and 45 healthy volunteers). The levels of potentially beneficial butyrate-producing bacteria were significantly reduced, while potentially pathogenic microorganisms such as and were enriched in T2D patients. We evaluated the correlation between clinical parameters and gut microbiota and identified the genera Bacteroides, , , and as possible detrimental factors in T2D. Our findings suggest that the gut microbiota may be a potential target in novel approaches to halt the development of T2D-associated complications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232315023