New HIV diagnoses in patients with COVID-19: two case reports and a brief literature review

COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentat...

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Bibliographic Details
Published in:BMC infectious diseases 2020-10, Vol.20 (1), p.771-771, Article 771
Main Authors: Zhang, Jiu-Cong, Yu, Xiao-Hui, Ding, Xiao-Han, Ma, Hao-Yu, Cai, Xiao-Qing, Kang, Sheng-Chao, Xiang, Da-Wei
Format: Article
Language:English
Subjects:
Adult
Betacoronavirus
Care and treatment
Case Report
China
Co-infection
Communicable diseases
Complications and side effects
Coronavirus Infections - complications
Coronavirus Infections - immunology
COVID-19
Disease susceptibility
Epidemiology
HIV
HIV infections
HIV Infections - complications
HIV Infections - diagnosis
HIV Infections - epidemiology
HIV Infections - immunology
HIV patients
Humans
Immunocompromised Host
Literature review
Male
Pandemics
Pneumonia, Viral - complications
Pneumonia, Viral - immunology
SARS-CoV-2
Sulbactam
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Summary:COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Severe cases developed life-threatening complications, such as respiratory failure, shock, and multiple organs dysfunction. Immunocompromised patients often present atypical presentations of viral infected diseases. We report newly diagnosed HIV infections in two patients with COVID-19 in China. In our two cases, both patients with elevated IL-6 received Tocilizumab treatment, but did not present obvious therapeutic effect. These cases highlight possible co-detection of known immunocompromised diseases such as HIV. The two cases we reported stressed the risk of misdiagnosis, especially during the pandemic of an infectious disease and the importance of extended testing even if in immune-compromised condition the immune state may be ignored.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-020-05480-y