Comparative Transcriptome Analysis Reveals the Innate Immune Response to Mycoplasma gallisepticum Infection in Chicken Embryos and Newly Hatched Chicks

( ) is a major cause of chronic respiratory diseases in chickens, with both horizontal and vertical transmission modes and varying degrees of impact on different ages. The innate immune response is crucial in resisting infection. Therefore, this study aimed to investigate the innate immune response...

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Bibliographic Details
Published in:Animals (Basel) 2023-05, Vol.13 (10), p.1667
Main Authors: Zou, Mengyun, Wang, Tengfei, Wang, Yingjie, Luo, Ronglong, Sun, Yingfei, Peng, Xiuli
Format: Article
Language:English
Subjects:
Antibiotics
Apoptosis
Cell adhesion & migration
Cell cycle
Chemokines
chick
chicken embryo
Chickens
Chicks
Cytokines
Disease control
Embryos
Genes
Genomes
Humidity
Immune response
Immune system
Infections
Inflammation
Innate immunity
International organizations
Juveniles
Laboratory animals
Lungs
Mycoplasma gallisepticum
Poultry
Proteins
Respiratory diseases
RNA-seq
Sequence analysis
Spleen
Thymus gland
TLR7 protein
Toll-like receptors
Transcriptomes
Vaccines
Weight loss
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Summary:( ) is a major cause of chronic respiratory diseases in chickens, with both horizontal and vertical transmission modes and varying degrees of impact on different ages. The innate immune response is crucial in resisting infection. Therefore, this study aimed to investigate the innate immune response of chicken embryos and newly hatched chicks to infection using comparative RNA-seq analysis. We found that infection caused weight loss and immune damage in both chicken embryos and chicks. Transcriptome sequencing analysis revealed that infected chicken embryos had a stronger immune response than chicks, as evidenced by the higher number of differentially expressed genes associated with innate immunity and inflammation. Toll-like receptor and cytokine-mediated pathways were the primary immune response pathways in both embryos and chicks. Furthermore, TLR7 signaling may play an essential role in the innate immune response to infection. Overall, this study sheds light on the development of innate immunity to infection in chickens and can help in devising disease control strategies.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani13101667