Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France

We recovered 2 carbapenem-resistant K2-ST86 hypermucoviscous Klebsiella pneumoniae isolates from patients in France. The isolates had genetic attributes of hypervirulent K. pneumoniae but differed in ability to cause mouse lethality. Convergence of hypervirulent K. pneumoniae toward resistance could...

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Bibliographic Details
Published in:Emerging infectious diseases 2020-07, Vol.26 (7), p.1529-1533
Main Authors: Beyrouthy, Racha, Dalmasso, Guillaume, Birer, Aurélien, Robin, Frédéric, Bonnet, Richard
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
antimicrobial resistance
Bacteriology
Biochemistry, Molecular Biology
Dispatch
Drug resistance
France
Genes
Genetic aspects
Genomes
Genotype & phenotype
Health aspects
hypervirulent Klebsiella pneumoniae
Imipenem
Life Sciences
Meropenem
Microbial drug resistance
Microbiology and Parasitology
Molecular biology
Mutation
next-generation sequencing
OXA-48
Oxalic acid
Plasmids
Pneumonia
Sepsis
Tigecycline
Urinary tract diseases
Urinary tract infections
Urogenital system
Virulence
Virulence (Microbiology)
β-lactamase
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Summary:We recovered 2 carbapenem-resistant K2-ST86 hypermucoviscous Klebsiella pneumoniae isolates from patients in France. The isolates had genetic attributes of hypervirulent K. pneumoniae but differed in ability to cause mouse lethality. Convergence of hypervirulent K. pneumoniae toward resistance could cause a health crisis because such strains could be responsible for severe and untreatable infections.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2607.191490