Insights from comparison of the clinical presentation and outcomes of patients hospitalized with COVID-19 in an Italian internal medicine ward during first and third wave

The reasons of variability of clinical presentation of coronavirus disease-19 (COVID-19) across different pandemic waves are not fully understood, and may include individual risk profile, SARS-CoV-2 lineage and seasonal variations of viral spread. The objective of this retrospective study was to com...

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Published in:Frontiers in medicine 2023-02, Vol.10, p.1112728-1112728
Main Authors: Ticinesi, Andrea, Parise, Alberto, Nouvenne, Antonio, Cerundolo, Nicoletta, Prati, Beatrice, Guerra, Angela, Tuttolomondo, Domenico, Gaibazzi, Nicola, Meschi, Tiziana
Format: Article
Language:English
Subjects:
B.1.1.7 lineage
care improvement
geriatric patients
Medicine
multimorbidity
respiratory failure
SARS-CoV-2
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Summary:The reasons of variability of clinical presentation of coronavirus disease-19 (COVID-19) across different pandemic waves are not fully understood, and may include individual risk profile, SARS-CoV-2 lineage and seasonal variations of viral spread. The objective of this retrospective study was to compare the characteristics and outcomes of patients admitted with confirmed coronavirus disease-19 (COVID-19) in the same season during the first (March 2020) and the third pandemic wave (March 2021, dominance of SARS-CoV-2 B.1.1.7 lineage) in an internal medicine ward of a large teaching hospital in Italy. Data of 769 unvaccinated patients (399 from the first and 370 from the third wave) were collected from clinical records, including symptom type and duration, extension of lung abnormalities on chest computed tomography (CT) and PaO /FiO ratio on admission arterial blood gas analysis. Third wave patients were in average younger (median 65, interquartile range [IQR] 55-75, vs. 72, IQR 61-81 years old,  
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2023.1112728