Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?

Psoriasis is a lifelong disease which requires treatment adherence for successful management. Considering the complexity of this pathology, the combination of active pharmaceutical ingredients with a synergistic mechanism of action can improve the safety and efficacy of the treatment with respect to...

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Bibliographic Details
Published in:Pharmaceutics 2022-09, Vol.14 (10), p.2085
Main Authors: Selmin, Francesca, Franzè, Silvia, Casiraghi, Antonella, Cilurzo, Francesco
Format: Article
Language:English
Subjects:
Betamethasone
Bioavailability
Caffeine
Calcipotriene
chemical compatibility
Clinical outcomes
Dermatitis
Disease
Dosage and administration
Drug dosages
Drug therapy
Drug therapy, Combination
epidermal barrier
Laboratory animals
Lipids
microneedles
nanovectors
Patients
Permeability
polyaphron dispersion
Psoriasis
psoriasis model
Review
Skin
Steroids
Testing
Vehicles
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Summary:Psoriasis is a lifelong disease which requires treatment adherence for successful management. Considering the complexity of this pathology, the combination of active pharmaceutical ingredients with a synergistic mechanism of action can improve the safety and efficacy of the treatment with respect to the conventional monotherapy. Moreover, a fixed dose of therapeutic agents in a topical formulation offers the possibility to simplify administration, reduce the doses of each active ingredient, and improve patient’s compliance. Among the first-line treatments in mild to moderate psoriasis, the formulation of calcipotriol (Cal) and betamethasone dipropionate (BD) in a single vehicle is challenging due to their chemical incompatibility in an aqueous environment and the formation of degradation products. Based on these considerations, this review aims to provide an overview on the biopharmaceutical properties of Cal/BD fixed-dose combination products available on the market (namely ointment, oleogel, foam, and O/W cream), highlighting also the novel approaches under evaluation. The main differences among topical formulations are discussed considering the different features of the anatomic districts involved in psoriasis and the patient’s adherence. Moreover, since in vitro experiments are fundamental to evaluate the skin permeation profile during the development of an efficacious medicinal product, special emphasis is given to models proposed to mimic psoriatic lesions.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14102085