The mechanisms and factors that induce trained immunity in arthropods and mollusks

Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modificati...

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Bibliographic Details
Published in:Frontiers in immunology 2023-09, Vol.14, p.1241934-1241934
Main Authors: Zhao, Mingming, Lin, Zhongyang, Zheng, Zhihong, Yao, Defu, Yang, Shen, Zhao, Yongzhen, Chen, Xiuli, Aweya, Jude Juventus, Zhang, Yueling
Format: Article
Language:English
Subjects:
arthropods
epigenetic modifications
Immunology
metabolism
mollusks
trained immunity
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Summary:Besides dividing the organism’s immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens’ reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1241934