The Role of MicroRNA in the Airway Surface Liquid Homeostasis

Mucociliary clearance, mediated by a coordinated function of cilia bathing in the airway surface liquid (ASL) on the surface of airway epithelium, protects the host from inhaled pathogens and is an essential component of the innate immunity. ASL is composed of the superficial mucus layer and the dee...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-06, Vol.21 (11), p.3848
Main Authors: Mitash, Nilay, Donovan, Joshua E., Swiatecka-Urban, Agnieszka
Format: Article
Language:English
Subjects:
airway host defense
Airway management
airway surface liquid
Bathing
Biosynthesis
Cilia
Cystic fibrosis
Epithelium
Gene expression
Homeostasis
Hydration
Innate immunity
Ion channels
microRNA
MicroRNAs
miRNA
miRNA-mRNA interaction
Mucus
Non-coding RNA
Pathogens
Post-transcription
Proteins
Regulators
Respiratory tract
Review
RNA-induced silencing complex
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Summary:Mucociliary clearance, mediated by a coordinated function of cilia bathing in the airway surface liquid (ASL) on the surface of airway epithelium, protects the host from inhaled pathogens and is an essential component of the innate immunity. ASL is composed of the superficial mucus layer and the deeper periciliary liquid. Ion channels, transporters, and pumps coordinate the transcellular and paracellular movement of ions and water to maintain the ASL volume and mucus hydration. microRNA (miRNA) is a class of non-coding, short single-stranded RNA regulating gene expression by post-transcriptional mechanisms. miRNAs have been increasingly recognized as essential regulators of ion channels and transporters responsible for ASL homeostasis. miRNAs also influence the airway host defense. We summarize the most up-to-date information on the role of miRNAs in ASL homeostasis and host–pathogen interactions in the airway and discuss concepts for miRNA-directed therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21113848