The Immunohistochemical Staining of Vimentin and E-Cadherin in Bladder Cancer Patients Infected with Hepatitis C Virus

The invasion and spread of cancer cells are two of the most notable characteristics of malignant tumors. Recent studies suggest that the epithelial-mesenchymal transition (EMT) has been linked to this significant occurrence. It is linked to the absence of the epithelial brow and the presence of mese...

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Published in:Journal of pure & applied microbiology : an international research journal of microbiology 2023-06, Vol.17 (2), p.1009-1016
Main Authors: Ismael, May K, Qaddoori, Yasir B, Shaban, Mustafa N, Al-Rubaii, Bahaa Abdullah Laftaah
Format: Article
Language:English
Subjects:
Bladder cancer
Cancer
Cancer patients
Care and treatment
e-cadherin
hcv
Health aspects
Hepatitis C virus
ihc
Immunohistochemistry
Oncology, Experimental
Stem cells
vimentin
Women
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Summary:The invasion and spread of cancer cells are two of the most notable characteristics of malignant tumors. Recent studies suggest that the epithelial-mesenchymal transition (EMT) has been linked to this significant occurrence. It is linked to the absence of the epithelial brow and the presence of mesenchymal facial hair. The aims of the present study were to explore the immunohistochemical staining of vimentin and E-cadherin ex vivo as EMT markers and assess their potential as predictive biomarkers for transitional cell cancer (TCC). In this study, 55 paraffin-embedded biopsies from TCC patients and 10 autopsies that appeared to be normal were included. Immunohistochemistry was used to produce patterns of vimentin and E-cadherin expression. When compared to female patients, the expression of E-cadherin and vimentin significantly increased with increasing age in male patients (> 50 years). In contrast to the considerable rise in vimentin expression in higher grades and stages of the tumor, E-cadherin expression was significantly reduced with tumor stage and grade. The findings of this study reveal that elevated vimentin and reduced E-cadherin are important indicators associated with a poor prognosis for TCC.
ISSN:0973-7510
2581-690X
DOI:10.22207/JPAM.17.2.30