Clinical outcomes of increased focal amyloid uptake in individuals with subthreshold global amyloid levels

Although the standardized uptake value ratio (SUVR) method is objective and simple, cut-off optimization using global SUVR values may not reflect focal increased uptake in the cerebrum. The present study investigated clinical and neuroimaging characteristics according to focally increased β-amyloid...

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Published in:Frontiers in aging neuroscience 2023-03, Vol.15, p.1124445-1124445
Main Authors: Kim, Jaeho, Choe, Yeong Sim, Park, Yuhyun, Kim, Yeshin, Kim, Jun Pyo, Jang, Hyemin, Kim, Hee Jin, Na, Duk L, Cho, Soo-Jin, Moon, Seung Hwan, Seo, Sang Won
Format: Article
Language:English
Subjects:
Aging Neuroscience
Alzheimer's disease
amyloid PET imaging
Atrophy
Cerebrum
Clinical outcomes
Clinical trials
Cognitive ability
Datasets
Dementia
florbetaben
flutemetamol
focal amyloid uptake
Hippocampus
Ligands
Medical imaging
Neostriatum
Neuroimaging
Positron emission tomography
Tomography
β-Amyloid
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Summary:Although the standardized uptake value ratio (SUVR) method is objective and simple, cut-off optimization using global SUVR values may not reflect focal increased uptake in the cerebrum. The present study investigated clinical and neuroimaging characteristics according to focally increased β-amyloid (Aβ) uptake and global Aβ status. We recruited 968 participants with cognitive continuum. All participants underwent neuropsychological tests and 498 F-florbetaben (FBB) amyloid positron emission tomography (PET) and 470 F-flutemetamol (FMM) PET. Each PET scan was assessed in 10 regions (left and right frontal, lateral temporal, parietal, cingulate, and striatum) with focal-quantitative SUVR-based cutoff values for each region by using an iterative outlier approach. A total of 62 (6.4%) subjects showed increased focal Aβ uptake with subthreshold global Aβ status [global (-) and focal (+) Aβ group, G(-)F(+) group]. The G(-)F(+) group showed worse performance in memory impairment (  
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2023.1124445