Prospective Clinical Study: Full-Body Blue Irradiation in the Treatment of Atopic Dermatitis

Introduction Ultraviolet-free (UV-free) blue light phototherapy has emerged as a promising option due to its reported efficacy and minimal adverse effects. This study aims to evaluate the effectiveness of full-body blue light irradiation in both adult and pediatric patients with atopic dermatitis (A...

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Published in:Dermatology and therapy 2024-09, Vol.14 (9), p.2631-2643
Main Authors: Sadowska, Magdalena, Narbutt, Joanna, Nolberczak, Daniel, Ciążyńska, Magdalena, Skibińska, Małgorzata, Sobolewska-Sztychny, Dorota, Aubert, David, Lesiak, Aleksandra
Format: Article
Language:English
Subjects:
Atopic dermatitis
Blue light
Brief Report
Care and treatment
Dermatology
Internal Medicine
Irradiation
Medicine
Medicine & Public Health
Methods
Monochromatic light
Mood regulation
Oral and Maxillofacial Surgery
Patient outcomes
Plastic Surgery
Quality of Life Research
Serotonin
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Summary:Introduction Ultraviolet-free (UV-free) blue light phototherapy has emerged as a promising option due to its reported efficacy and minimal adverse effects. This study aims to evaluate the effectiveness of full-body blue light irradiation in both adult and pediatric patients with atopic dermatitis (AD), assessing its impact on skin condition and mood regulation by investigating serum concentrations of serotonin and kynurenine pathway metabolites. Methods 20 patients (age 9–45) with moderate and severe AD were included in the study. Treatment consisted of 10 irradiations with Full Body Blue device (453 nm). Serum concentrations of serotonin, quinolinic acid, kynurenic acid, tryptophan, and kynurenine were measured before and after irradiations. Results After 10 sessions of full blue light therapy (453 nm) statistically significant improvements were observed in Eczema Area Severity Index (EASI 13.16 vs. 8.65; p  = 0.00016), SCORing Atopic Dermatitis (SCORAD 44.99 vs. 23.73; p  
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-024-01248-3