Lymph node ratio is inferior to pN-stage in predicting outcome in colon cancer patients with high numbers of analyzed lymph nodes

The lymph node ratio (LNR), i.e. the number of positive lymph nodes (LN) divided by the total number of analyzed LN, has been described as a strong outcome predictor in node-positive colon cancer patients. However, most published analyses are constrained by relatively low numbers of analyzed LN. The...

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Bibliographic Details
Published in:BMC surgery 2018-10, Vol.18 (1), p.81-81, Article 81
Main Authors: Jakob, Manuel O, Guller, Ulrich, Ochsner, Alex, Oertli, Daniel, Zuber, Markus, Viehl, Carsten T
Format: Article
Language:English
Subjects:
Abdomen
Aged
Aged, 80 and over
Biopsy
Cancer
Cancer patients
Cancer surgery
Chemotherapy
Colectomy
Colon
Colon cancer
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Colorectal cancer
Disease-Free Survival
Female
Health aspects
Humans
Lymph Node Excision
Lymph node ratio
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Male
Medical prognosis
Metastasis
Middle Aged
Neoplasm Staging
Outcome
Patients
pN-stage
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Studies
Survival
Survival Rate
Systematic review
Treatment Outcome
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Summary:The lymph node ratio (LNR), i.e. the number of positive lymph nodes (LN) divided by the total number of analyzed LN, has been described as a strong outcome predictor in node-positive colon cancer patients. However, most published analyses are constrained by relatively low numbers of analyzed LN. Therefore, the objective of the present study was to evaluate the prognostic impact of LNR in colon cancer patients with high numbers of analyzed LN. One hundred sixty-six colon cancer patients underwent open colon resection. All node-positive patients were analyzed for this study. The number of analyzed LN, of positive LN, the disease-free (DFS) and overall survival (OS) time were prospectively recorded. Patients were dichotomously allocated to a high or a low LNR-group, respectively, with the median LNR (0.125) as a cut-off value. Median follow-up was 34.3 months. Fifty-eight patients (34.9%) were node-positive. The median number of analyzed LN was 23 (range 8-54). DFS and OS were significantly shorter in pN2 vs pN1 patients (p 
ISSN:1471-2482
1471-2482
DOI:10.1186/s12893-018-0417-0