Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population

Widespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, abnormaliti...

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Published in:Scientific reports 2023-06, Vol.13 (1), p.9484-9484, Article 9484
Main Authors: Teiri, Hakimeh, Samaei, Mohammad Reza, Dehghani, Mansooreh, Azhdarpoor, Abooalfazl, Mohammadi, Farzaneh, Kelishadi, Roya, Hajizadeh, Yaghoub
Format: Article
Language:English
Subjects:
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Benzophenone
Birth weight
Fetuses
Humanities and Social Sciences
Infants
Metabolites
multidisciplinary
Neonates
Offspring
Phenolic compounds
Phenols
Ponderal index
Pregnancy
Prenatal experience
Prenatal exposure
Science
Science (multidisciplinary)
Thorax
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Summary:Widespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, abnormalities, corpulence index and anterior fontanelle diameter (AFD) was investigated. Mother-infant pairs of 166 within PERSIAN cohort population in Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy were assessed. Four common benzophenone metabolites including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP) and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median concentration of 4-OH-BP, BP-3, BP-1 and BP-8 were 3.15, 16.98, 9.95 and 1.04 µg/g Cr, respectively. In the 1st trimester, 4-OH-BP showed a significant correlation with AFD in total infants, decreasing 0.034 cm AFD per a log unit increase of 4-OH-BP. Within the male neonates, 4-OH-BP in the 1st and BP-8 in the 3rd trimester were significantly associated with head circumference and AFD increase, respectively. Among female neonates in the 3rd trimester, increasing 4-OH-BP and BP-3 concentration was correlated with a decrease in birth weight and AFD, respectively. This study demonstrated that all the target BP derivatives can influence normal fetal growth at any age of the pregnancy, nevertheless, to support these findings further studies are needed in a large and different group population.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-35380-5