Stomach secretes estrogen in response to the blood triglyceride levels

Mammals receive body energy information to maintain energy homeostasis. Ghrelin, insulin, leptin and vagal afferents transmit the status of fasting, blood glucose, body fat, and food intake, respectively. Estrogen also inhibits feeding behavior and lipogenesis, but increases body fat mass. However,...

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Bibliographic Details
Published in:Communications biology 2021-12, Vol.4 (1), p.1364-1364, Article 1364
Main Authors: Ito, Takao, Yamamoto, Yuta, Yamagishi, Naoko, Kanai, Yoshimitsu
Format: Article
Language:English
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Adipocytes
Animals
Biology
Biomedical and Life Sciences
Blood glucose
Body fat
Energy balance
Epithelium
Estrogens
Estrogens - biosynthesis
Fatty acids
Feeding behavior
Female
Food intake
Gastric glands
Ghrelin
Homeostasis
Insulin
Leptin
Life Sciences
Lipogenesis
Male
Parietal cells
Rats
Rats, Wistar
Stomach
Stomach - metabolism
Triglycerides - blood
Vagus nerve
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Summary:Mammals receive body energy information to maintain energy homeostasis. Ghrelin, insulin, leptin and vagal afferents transmit the status of fasting, blood glucose, body fat, and food intake, respectively. Estrogen also inhibits feeding behavior and lipogenesis, but increases body fat mass. However, how blood triglyceride levels are monitored and the physiological roles of estrogen from the perspective of lipid homeostasis remain unsettled. Here, we show that stomach secretes estrogen in response to the blood triglyceride levels. Estrogen-secreting gastric parietal cells predominantly use fatty acids as an energy source. Blood estrogen levels increase as blood triglyceride levels rise in a stomach-dependent manner. Estrogen levels in stomach tissues increase as blood triglyceride levels rise, and isolated gastric gland epithelium produces estrogen in a fatty acid-dependent manner. We therefore propose that stomach monitors and controls blood triglyceride levels using estrogen, which inhibits feeding behavior and lipogenesis, and promotes triglyceride uptake by adipocytes. Ito et al. demonstrate that murine gastric parietal cells produce estrogen using fatty acids as an energy source, and secrete estrogen in response to the blood triglyceride levels. The authors propose that the stomach is involved in the monitoring and the regulation of blood triglyceride levels.
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-021-02901-9