Significant increase in anti-SARS-CoV-2 antibodies after administration of heterologous mRNA-based vaccine booster in individuals receiving two doses of inactivated COVID-19 vaccine: A single-center study in healthcare workers in Jakarta, Indonesia

Vaccine plays an important role in breaking SARS-CoV-2 transmission and accelerating the path to pandemic recovery. Currently, there is still limited data on heterologous COVID-19 booster vaccination efficacy and effectiveness in Indonesia. Antibody response was retrospectively analyzed from 156 ser...

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Published in:Journal of infection and public health 2023-11, Vol.16 (11), p.1848-1851
Main Authors: Setiadi, Wuryantari, Effendi, Qothrunnada, Johar, Edison, Yohan, Benediktus, Wibowo, Dhita Prabasari, Syahrani, Lepa, Pramono, Alana Arumsari, Kartapradja, Hannie H., Yudhaputri, Frilasita Aisyah, Dewi, Beti Ernawati, Malik, Safarina G., Myint, Khin Saw Aye, Soebandrio, Amin, Safari, Dodi
Format: Article
Language:English
Subjects:
2019-nCoV Vaccine mRNA-1273
Antibodies, Viral
Booster
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines
Health Personnel
Humans
IgA
IgG
Immunoglobulin A
Indonesia - epidemiology
MRNA vaccine
Retrospective Studies
RNA, Messenger
SARS-CoV-2
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Summary:Vaccine plays an important role in breaking SARS-CoV-2 transmission and accelerating the path to pandemic recovery. Currently, there is still limited data on heterologous COVID-19 booster vaccination efficacy and effectiveness in Indonesia. Antibody response was retrospectively analyzed from 156 serum collected from healthcare workers that have received mRNA-1273 vaccine as the booster against SARS-CoV-2. These individuals had previously received the full two doses of inactivated anti-SARS-CoV-2 vaccine. Serological analysis was performed to measure total antibody, as well as IgA and IgG antibodies specific to spike (S) protein using ECLIA and ELISA methods. A significant increase in total, IgA, and IgG antibody titers was reported in vaccine receiving a third heterologous booster dose of mRNA-based COVID-19 vaccine following two doses of inactivated type. The third heterologous booster dose of vaccine may be beneficial to individuals with or without previous history of SARS-CoV-2 infection.
ISSN:1876-0341
1876-035X
DOI:10.1016/j.jiph.2023.09.012