Touring Ensembl: a practical guide to genome browsing

The number of databases in molecular biological fields has rapidly increased to provide a large-scale resource. Though valuable information is available, data can be difficult to access, compare and integrate due to different formats and presentations of web interfaces. This paper offers a practical...

Full description

Saved in:
Bibliographic Details
Published in:BMC genomics 2010-05, Vol.11 (1), p.295-295
Main Authors: Spudich, Giulietta M, Fernández-Suárez, Xosé M
Format: Article
Language:English
Subjects:
Analysis
Animals
Base Sequence
Chordata
Conserved Sequence
Correspondence
Databases, Genetic
Genealogical libraries
Genomics - methods
Humans
Interleukin-2 - genetics
Internet
Mice
Molecular Sequence Data
Polymorphism, Single Nucleotide
Rats
Regulatory Sequences, Nucleic Acid - genetics
User-Computer Interface
Web browsers
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The number of databases in molecular biological fields has rapidly increased to provide a large-scale resource. Though valuable information is available, data can be difficult to access, compare and integrate due to different formats and presentations of web interfaces. This paper offers a practical guide to the integration of gene, comparative genomic, and functional genomics data using the Ensembl website at http://www.ensembl.org.The Ensembl genome browser and underlying databases focus on chordate organisms. More species such as plants and microorganisms can be investigated using our sister browser at http://www.ensemblgenomes.org.In this study, four examples are used that sample many pages and features of the Ensembl browser. We focus on comparative studies across over 50 mostly chordate organisms, variations linked to disease, functional genomics, and access of external information housed in databases outside the Ensembl project. Researchers will learn how to go beyond simply exporting one gene sequence, and explore how a genome browser can integrate data from various sources and databases to build a full and comprehensive biological picture.
ISSN:1471-2164
1471-2164
DOI:10.1186/1471-2164-11-295