The Role of Tubulin Polymerization-Promoting Protein2 (TPPP2) in Spermatogenesis: A Narrative Review

Tubulin polymerization-promoting protein2 (TPPP2) is one of the three paralogs of mammalian TPPP proteins. Its possible role in spermatogenesis is described in this narrative review. TPPP2 is expressed specifically in the male reproductive system, mainly in testes and sperm, and also in the epididym...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (13), p.7017
Main Author: Orosz, Ferenc
Format: Article
Language:English
Subjects:
Animals
Cancer
epididymis
flagellum
Genes
Genomes
Humans
Infertility
Male
Mass spectrometry
Mice
Mice, Knockout
Motility
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
oligoasthenozoospermia
Polymerization
Protein expression
Proteins
Scientific imaging
Sperm
Sperm Motility - genetics
Spermatogenesis
spermatozoa
Spermatozoa - metabolism
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Summary:Tubulin polymerization-promoting protein2 (TPPP2) is one of the three paralogs of mammalian TPPP proteins. Its possible role in spermatogenesis is described in this narrative review. TPPP2 is expressed specifically in the male reproductive system, mainly in testes and sperm, and also in the epididymis. In testes, TPPP2 is exclusively expressed in elongating spermatids; in the epididymis, it is located in the middle piece of the sperm tail. TPPP2 is involved in spermiogenesis, in steps which are determinative for the formation and morphology of spermatids. The inhibition of TPPP2 decreases sperm motility (the curvilinear velocity of sperms), probably due to influencing mitochondrial energy production since TPPP2 knockout mice possess an impaired mitochondrial structure. There are data on the role of TPPP2 in various mammalian species: human, mouse, swine, and various ruminants; there is a significant homology among TPPP2s from different species. Experiments with -mice show that the absence of TPPP2 results in decreased sperm count and serious dysfunction of sperm, including decreased motility; however, the in vitro capacitation and acrosome reaction are not influenced. The symptoms show that -mice may be considered as a model for oligoasthenozoospermia.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25137017