Suspected bias in selection criteria of target subpopulation and its validation

[...]there will appear to be a large difference in mortality rates between the intervention and control groups in a population that is likely to experience early mortality after observation. [...]the selection criteria for patients who are expected to have a large treatment effect could be influence...

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Bibliographic Details
Published in:Critical care (London, England) England), 2023-07, Vol.27 (1), p.284-284, Article 284
Main Authors: Uchida, Masatoshi, Hayashi, Kentaro
Format: Article
Language:English
Subjects:
Bias
Correspondence
Critical care
Health Services Needs and Demand
Hemadsorption
Humans
Mortality
Patient Selection
Patients
Polymyxin B
Sepsis
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Summary:[...]there will appear to be a large difference in mortality rates between the intervention and control groups in a population that is likely to experience early mortality after observation. [...]the selection criteria for patients who are expected to have a large treatment effect could be influenced by this bias. [...]the results of the study could be affected by survivor treatment selection bias and these criteria may not capture patients who may benefit most from PMX-HA.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-023-04566-8