The Ethanolic Extract of Gomphrena celosioides Mart. Does Not Alter Reproductive Performance or Embryo-Fetal Development, nor Does It Cause Chromosomal Damage

• Published in: Pharmaceutics 2022-11, Vol.14 (11), p.2369
• Main Authors: Salustriano, Fabricia Rodrigues, Monreal, Antonio Carlos Duenhas, das Neves, Silvia Cordeiro, de Oliveira, Giovana Martins, de Oliveira, Diego Duarte Marques, Vilela, Marcelo Luiz Brandão, do Nascimento, Valter Aragão, Martins, Allana Cristina Faustino, Saroja, Baby, Karuppusamy, Arunachalam, Coelho, Henrique Rodrigues Scherer, Kassuya, Candida Aparecida Leite, Gelves, Dayanna Isabel Araque, Salvador, Marcos José, Oliveira, Rodrigo Juliano, Gomes, Roberto da Silva
• Format: Article
• Language: English
• Subjects: Alcohol; Animals; Antihypertensives; chromosomal damage; Diuretics; Fetuses; Gomphrena celosioides; Males; Ostomy; teratogenesis; Toxicity
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics14112369

is a native Brazilian plant found in the State of Mato Grosso do Sul. It is used in folk medicine to treat kidney diseases, skin diseases, infections, rheumatism, gastrointestinal diseases, and respiratory diseases. It is also used as an abortifacient. To evaluate the effects of the ethanolic extract of (EEGc) on reproductive performance, embryo development, and chromosome stability, Swiss mice were randomly divided into experimental groups ( = 10). The animals in the control group received the vehicle Tween 80-1% in the proportion of 0.1 mL/10 g of body weight orally, from the first to the 18th gestational day. The animals in the treatment groups received the EEGc (100, 1000, and 2000 mg/kg) from the first to the 18th gestational day. The animals underwent evaluations of their reproductive performance and embryofetal development. The results showed that the EEGc did not change the animals' final weight, weight gain, uterine weight, or net weight gain. The evaluation showed that the absolute and relative organs' weights did not vary between the different experimental groups. In addition, the EEGc did not change the numbers of implants, live fetuses, dead fetuses, or fetal resorptions. There were no differences in post-operative loss rates, implantations, or resorptions, nor were there differences in fetal viability or sex ratio. The use of the EEGc did not result in different frequencies of malformations. In addition, the EEGc did not alter the frequency of chromosomal damage or frequency of micronuclei. Based on our findings, we considered the extract of to be safe for use during pregnancy, although some parameters indicated caution in its use.