(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees

Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2009-07, Vol.14 (8), p.2850-2856
Main Authors: Rachmatiah, Tiah, Mukhtar, Mat Ropi, Nafiah, Mohd Azlan, Hanafi, Muhammad, Kosela, Soleh, Morita, Hiroshi, Litaudon, Marc, Awang, Khalijah, Omar, Hanita, Hadi, A Hamid A
Format: Article
Language:English
Subjects:
Actinodaphne pruinosa
Animals
aporphine alkaloid
Aporphines
Aporphines - chemistry
Aporphines - isolation & purification
Aporphines - pharmacology
Cell Line, Tumor
Cell Survival
Cell Survival - drug effects
Cellular Biology
Chemistry
cytotoxic
Cytotoxicity
Cytotoxins
Cytotoxins - chemistry
Cytotoxins - isolation & purification
Cytotoxins - pharmacology
Lauraceae
Lauraceae - chemistry
Life Sciences
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Molecular Structure
Plant Stems
Plant Stems - chemistry
Science
Spectrophotometry, Ultraviolet
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Summary:Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC(50 )value of 3.9 microg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules14082850