Clinical Outcomes of Drug-Eluting versus Bare-Metal In-Stent Restenosis after the Treatment of Drug-Eluting Stent or Drug-Eluting Balloon: A Systematic Review and Meta-Analysis

Background. Although drug-eluting stents (DES) have reduced the rates of in-stent restenosis (ISR) compared with bare-metal stents (BMS), DES related ISR (DES-ISR) still occurs and outcomes of DES-ISR remain unclear. The objective of this meta-analysis was to investigate the long-term clinical outco...

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Bibliographic Details
Published in:Journal of interventional cardiology 2020, Vol.2020 (2020), p.1-11
Main Authors: Wang, Jiao, Lu, Peng-Ju, Li, Chang-Ping, Liu, Yin, Yang, Yi-Xing, Gao, Jing
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Balloon treatment
Bias
Cadmium
Clinical outcomes
Comparative analysis
Comparative Effectiveness Research
Coronary Restenosis - surgery
Drug delivery
Drug-Eluting Stents - adverse effects
Heart
Heart attacks
Humans
Implants
Medical research
Medicine, Experimental
Meta-analysis
Myocardial infarction
Myocardial Ischemia - mortality
Myocardial Ischemia - surgery
Myocardial Revascularization - adverse effects
Myocardial Revascularization - instrumentation
Myocardial Revascularization - methods
Patients
Restenosis
Stent (Surgery)
Stents
Stents - adverse effects
Stents - classification
Studies
Thrombosis
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Summary:Background. Although drug-eluting stents (DES) have reduced the rates of in-stent restenosis (ISR) compared with bare-metal stents (BMS), DES related ISR (DES-ISR) still occurs and outcomes of DES-ISR remain unclear. The objective of this meta-analysis was to investigate the long-term clinical outcomes of patients with DES-ISR compared with patients with BMS related ISR (BMS-ISR) after the treatment of DES or drug-eluting balloon (DEB). Methods and results. We searched the literature in the main electronic databases including PUBMED, EMBASE, Cochrane Library, and Web of Science. The primary endpoints were target lesion revascularization (TLR) and target vessel revascularization (TVR). The secondary endpoints included all cause death (ACD), cardiac death (CD), myocardial infarction (MI), stent thrombosis or re-in-stent restenosis (ST/RE-ISR), and major adverse cardiovascular events (MACEs). A total of 19 studies with 6256 participants were finally included in this meta-analysis. Results showed that the rates of TLR (P
ISSN:0896-4327
1540-8183
DOI:10.1155/2020/8179849