Native chemical ligation: a boon to peptide chemistry

The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the entry of peptides into the world of viable oral ther...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2014-09, Vol.19 (9), p.14461-14483
Main Authors: Thapa, Parashar, Zhang, Rui-Yang, Menon, Vinay, Bingham, Jon-Paul
Format: Article
Language:English
Subjects:
auxiliary
Chemistry, Pharmaceutical
conotoxin
Conotoxins - chemistry
convergent
cyclotides
Cyclotides - chemistry
Cysteine - chemistry
Humans
native chemical ligation
Oximes - chemistry
Peptides - chemistry
Peptides - therapeutic use
Proteins - chemistry
Proteins - therapeutic use
Review
sequential
thioester
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Summary:The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the entry of peptides into the world of viable oral therapeutic drugs through peptide backbone cyclization. This progression has been a journey of chemical exploration and transition, leading to the dominance of native chemical ligation in the present advances of peptide/protein applications. Here we illustrate and explore the historical and current nature of peptide ligation, providing a clear indication to the possibilities and use of these novel methods to take peptides outside their typically defined boundaries.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules190914461