Cancer risk after renal transplantation in South Korea: a nationwide population-based study

This study aimed to evaluate patterns of posttransplant malignancies among renal transplant recipients (RTRs) in South Korea using nationwide data. The nationwide cohort assessed in this study included RTRs from January 1, 2010, to December 31, 2014. We analyzed cancer incidence during the time cour...

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Published in:BMC nephrology 2018-11, Vol.19 (1), p.311-311, Article 311
Main Authors: Heo, Jaesung, Noh, O Kyu, Oh, Young-Taek, Chun, Mison, Kim, Logyoung
Format: Article
Language:English
Subjects:
Age
Breast cancer
Codes
Disease
Gastric cancer
Health risk assessment
Kidney cancer
Kidney transplantation
Lymphoma
Males
Malignancy
Medical prognosis
Mortality
Multiple myeloma
Myeloma
Nephrology
Population
Population studies
Population-based studies
Renal transplantation
Screening
South Korea
Studies
Thyroid cancer
Transplants & implants
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container_title BMC nephrology
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creator Heo, Jaesung
Noh, O Kyu
Oh, Young-Taek
Chun, Mison
Kim, Logyoung
description This study aimed to evaluate patterns of posttransplant malignancies among renal transplant recipients (RTRs) in South Korea using nationwide data. The nationwide cohort assessed in this study included RTRs from January 1, 2010, to December 31, 2014. We analyzed cancer incidence during the time course after renal transplantation. Additionally, we calculated standardized incidence ratios (SIRs) to evaluate the risk of malignancies in RTRs. A total of 1343 RTRs (871 males and 472 females, mean age 48.5 ± 11.6 years) were assessed. Among them, 104 (7.7%) developed malignancies after transplantation, most commonly in the thyroid cancer (23.1%). The SIR for all cancers was 3.54; particularly, the SIRs for renal cancer, myeloma, and non-Hodgkin lymphoma were 16.31, 24.02, and 28.64, respectively. Females showed a higher risk of malignancy than males (SIRs: 4.04 for women and 3.26 for men). The median interval between transplantation and malignancy diagnosis was 27.2 months (range 12.3-54.8 months). RTRs in South Korea demonstrated a high risk of malignancy after transplantation compared with the general population. This indicates that close surveillance and routine screening for cancer in RTRs are needed.
doi_str_mv 10.1186/s12882-018-1110-3
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subjects Age
Breast cancer
Codes
Disease
Gastric cancer
Health risk assessment
Kidney cancer
Kidney transplantation
Lymphoma
Males
Malignancy
Medical prognosis
Mortality
Multiple myeloma
Myeloma
Nephrology
Population
Population studies
Population-based studies
Renal transplantation
Screening
South Korea
Studies
Thyroid cancer
Transplants & implants
title Cancer risk after renal transplantation in South Korea: a nationwide population-based study
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