Mojabanchromanol Isolated from Sargassum horneri Attenuates Particulate Matter Induced Inflammatory Responses via Suppressing TLR2/4/7-MAPK Signaling in MLE-12 Cells

Chromanols from marine algae are studied for drug development due to its prominent bioactive properties, and mojabanchromanol (MC), a chromanol isolated from a brown algae , is found to possess anti-oxidant potential. In this study, we hypothesized MC may attenuate particulate matter (PM)-induced an...

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Bibliographic Details
Published in:Marine drugs 2020-07, Vol.18 (7), p.355
Main Authors: Herath, Kalahe Hewage Iresha Nadeeka Madushani, Kim, Hyo Jin, Jang, Jae-Hyuk, Kim, Hyun-Soo, Kim, Hyun Jung, Jeon, You-Jin, Jee, Youngheun
Format: Article
Language:English
Subjects:
8-Hydroxydeoxyguanosine
Algae
Alveolar Epithelial Cells - drug effects
Alveoli
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Asthma
Attenuation
Cell activation
Cell growth
Chemical compounds
Chromans - pharmacology
Cytokines
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Drug development
Epithelial cells
Extracellular
Extracellular signal-regulated kinase
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
IL-1β
IL-6
Inflammation
Inflammatory diseases
Interleukin 6
Kinases
Lipid peroxidation
Lipids
Lungs
Malondialdehyde
MAP kinase
MAPK
Mojabanchromanol
Organic chemicals
Oxidants
Oxidative stress
Oxidizing agents
Particulate emissions
Particulate matter
Peroxidation
Pharmacology
Phosphorylation
Protein kinase
Reactive oxygen species
Respiratory tract diseases
Sargassum
Sargassum horneri
Secretion
Signal Transduction - drug effects
Signaling
Suspended particulate matter
TLR2 protein
TLR2/4/7
Toll-Like Receptor 2 - metabolism
Toll-like receptors
Transcription factors
Tumor necrosis factor-TNF
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Summary:Chromanols from marine algae are studied for drug development due to its prominent bioactive properties, and mojabanchromanol (MC), a chromanol isolated from a brown algae , is found to possess anti-oxidant potential. In this study, we hypothesized MC may attenuate particulate matter (PM)-induced and reactive oxygen species (ROS)-mediated inflammatory responses in airways and tried to identify its potential and underlying mechanism against PM (majority
ISSN:1660-3397
1660-3397
DOI:10.3390/md18070355