A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA

Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to resear...

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Bibliographic Details
Published in:Journal of analytical methods in chemistry 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Nandi, Anirban, Pan, Sharadwata, Potumarthi, Ravichandra, Danquah, Michael K., Sarethy, Indira P.
Format: Article
Language:English
Subjects:
Antibiotics
Chemical engineering
Chemical properties
Chemical reactions
Chemical synthesis
Chromatography
Conversion
Deoxyribonucleic acid
DNA
E coli
Enzymes
Fermentation
Gene expression
Mass production
Mathematical analysis
Methodology
Methods
Penicillin
Penicillin G
Pharmaceutical industry
Production processes
Proposals
Quality assurance
Research and development
Review
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Summary:Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.
ISSN:2090-8865
2090-8873
DOI:10.1155/2014/413616