Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis

• Published in: Breast cancer research : BCR 2020-01, Vol.22 (1), p.11-11, Article 11
• Main Authors: Chaudhary, Pankaj, Gibbs, Lee D, Maji, Sayantan, Lewis, Cheryl M, Suzuki, Sumihiro, Vishwanatha, Jamboor K
• Format: Article
• Language: English
• Subjects: African Americans; Analysis; And racial disparity; Angiogenesis; Animals; Annexin A2; Annexin A2 - blood; Annexins; Biomarkers, Tumor - blood; Black or African American - statistics & numerical data; Breast cancer; Cancer metastasis; Cancer patients; ErbB-2 protein; Exosomes; Exosomes - metabolism; Female; Females; Growth factors; Hemoglobin; Humans; Metastases; Metastasis; Mice; Mice, Nude; Mortality; Neoplasm Grading; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Peptides; Proteins; ROC Curve; Signal transduction; Survival; Triple Negative Breast Neoplasms - blood supply; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Tumors; Women; Womens health
• ISSN: 1465-542X; 1465-5411; 1465-542X
• DOI: 10.1186/s13058-020-1251-8

Limited information is available on biomarker(s) for triple-negative breast cancer (TNBC) that can address the higher incidence and aggressiveness of TNBC in African-American (AA) women. Our previous studies have demonstrated annexin A2 (AnxA2) association with exosomes which promotes angiogenesis and metastasis. Therefore, our goal was to examine the expression and function of exosomal-annexin A2 (exo-AnxA2) derived from the serum samples of breast cancer patients. The expression of serum exo-AnxA2 and its association with clinicopathological features of the breast cancer patients were determined. The role of serum exo-AnxA2 to promote angiogenesis was determined by an in vivo Matrigel plug assay. Our results show that the expression of serum exo-AnxA2 in breast cancer patients (n = 169; 83.33 ± 2.040 ng/mL, P