Rational design and latest advances of codelivery systems for cancer therapy

Current treatments have limited effectiveness in treating tumors. The combination of multiple drugs or treatment strategies is widely studied to improve therapeutic effect and reduce adverse effects of cancer therapy. The codelivery system is the key to realize combined therapies. It is necessary to...

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Bibliographic Details
Published in:Materials today bio 2020-06, Vol.7, p.100056, Article 100056
Main Authors: Meng, Q.Y., Cong, H.L., Hu, H., Xu, F.-J.
Format: Article
Language:English
Subjects:
Chemotherapy
Codelivery system
Gene therapy
Immunotherapy
Phototherapy
Review
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Summary:Current treatments have limited effectiveness in treating tumors. The combination of multiple drugs or treatment strategies is widely studied to improve therapeutic effect and reduce adverse effects of cancer therapy. The codelivery system is the key to realize combined therapies. It is necessary to design and construct different codelivery systems in accordance with the variable structures and properties of cargoes and vectors. This review presented the typical design considerations about codelivery vectors for cancer therapy and described the current state of codelivery systems from two aspects: different types of vectors and collaborative treatment strategies. The commonly used loading methods of cargoes into the vectors, including physical and chemical processes, are discussed in detail. Finally, we outline the challenges and perspectives about the improvement of codelivery systems. [Display omitted]
ISSN:2590-0064
2590-0064
DOI:10.1016/j.mtbio.2020.100056