Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography

To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were r...

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Bibliographic Details
Published in:Scientific reports 2021-12, Vol.11 (1), p.23493-23493, Article 23493
Main Authors: Agarwal, Aniruddha, Kalra, Gagan, Agrawal, Rupesh, Bansal, Reema, Gupta, Vishali
Format: Article
Language:English
Subjects:
692/308/53
692/699/3161
Adult
Atrophy
Automation
Choroid - physiopathology
Choroiditis
Choroiditis - physiopathology
Evaluation Studies as Topic
Eye
Female
Humanities and Social Sciences
Humans
Male
Membranes - physiopathology
multidisciplinary
Patients
Quantitative analysis
Retina
Retina - physiopathology
Retrospective Studies
Science
Science (multidisciplinary)
Tomography
Tomography, Optical Coherence - methods
Tuberculosis, Ocular - physiopathology
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Summary:To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three OCT scans were chosen—one passing through the center of the fovea, one line above, and one line below. After random indexing to anonymize the images, they were pre-processed and fed into an automated pipeline to identify, crop, and measure the area of the OPL in the line scan. Longitudinal comparisons of OPL within the patient group were performed. The study included 32 eyes (16 patients; 11 males; mean age: 32.9 ± 7.8 years) with TB SLC. Twenty-eight eyes (14 subjects; 10 males: mean age: 31.1 ± 6.2 years) of healthy control subjects (age- and gender-matched) were also selected. The area of OPL was significantly different between the baseline and month 6 visit (6288 ± 1803 versus 5487 ± 1461; p  = 0.0002) at the central scan passing through the fovea. For the scans above and below the fovea, the reduction in OPL area was significant at each visit ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-02894-9