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Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography
To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were r...
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| Published in: | Scientific reports 2021-12, Vol.11 (1), p.23493-23493, Article 23493 |
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| description | To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three OCT scans were chosen—one passing through the center of the fovea, one line above, and one line below. After random indexing to anonymize the images, they were pre-processed and fed into an automated pipeline to identify, crop, and measure the area of the OPL in the line scan. Longitudinal comparisons of OPL within the patient group were performed. The study included 32 eyes (16 patients; 11 males; mean age: 32.9 ± 7.8 years) with TB SLC. Twenty-eight eyes (14 subjects; 10 males: mean age: 31.1 ± 6.2 years) of healthy control subjects (age- and gender-matched) were also selected. The area of OPL was significantly different between the baseline and month 6 visit (6288 ± 1803 versus 5487 ± 1461;
p
= 0.0002) at the central scan passing through the fovea. For the scans above and below the fovea, the reduction in OPL area was significant at each visit (
p
|
| doi_str_mv | 10.1038/s41598-021-02894-9 |
| format | article |
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p
= 0.0002) at the central scan passing through the fovea. For the scans above and below the fovea, the reduction in OPL area was significant at each visit (
p
< 0.0001). In comparison with healthy control subjects, OPL area values in patients with TB SLC were significantly lower at the month-3 (6116 ± 1441 versus 7136 ± 2539;
p
= 0.04) and the 6-month visit (5487 ± 1461 versus 7136 ± 2539;
p
< 0.001). The atrophied OPL at month 6 has been referred to as the “middle limiting membrane” (MLM). Subjects with TB SLC may develop progressive atrophy of the OPL resulting in formation of MLM, which is seen as a hyper-reflective line replacing the OPL. The analysis of longitudinal changes in the OPL may be useful in predicting anatomical and functional outcomes in these patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-02894-9</identifier><identifier>PMID: 34873214</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/53 ; 692/699/3161 ; Adult ; Atrophy ; Automation ; Choroid - physiopathology ; Choroiditis ; Choroiditis - physiopathology ; Evaluation Studies as Topic ; Eye ; Female ; Humanities and Social Sciences ; Humans ; Male ; Membranes - physiopathology ; multidisciplinary ; Patients ; Quantitative analysis ; Retina ; Retina - physiopathology ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Tomography ; Tomography, Optical Coherence - methods ; Tuberculosis, Ocular - physiopathology</subject><ispartof>Scientific reports, 2021-12, Vol.11 (1), p.23493-23493, Article 23493</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-9e7afc5f3f176a0b72480ae786302c384fe002825c201bf58306c60e0a602f3e3</citedby><cites>FETCH-LOGICAL-c540t-9e7afc5f3f176a0b72480ae786302c384fe002825c201bf58306c60e0a602f3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2607083695/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2607083695?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34873214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, Aniruddha</creatorcontrib><creatorcontrib>Kalra, Gagan</creatorcontrib><creatorcontrib>Agrawal, Rupesh</creatorcontrib><creatorcontrib>Bansal, Reema</creatorcontrib><creatorcontrib>Gupta, Vishali</creatorcontrib><title>Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three OCT scans were chosen—one passing through the center of the fovea, one line above, and one line below. After random indexing to anonymize the images, they were pre-processed and fed into an automated pipeline to identify, crop, and measure the area of the OPL in the line scan. Longitudinal comparisons of OPL within the patient group were performed. The study included 32 eyes (16 patients; 11 males; mean age: 32.9 ± 7.8 years) with TB SLC. Twenty-eight eyes (14 subjects; 10 males: mean age: 31.1 ± 6.2 years) of healthy control subjects (age- and gender-matched) were also selected. The area of OPL was significantly different between the baseline and month 6 visit (6288 ± 1803 versus 5487 ± 1461;
p
= 0.0002) at the central scan passing through the fovea. For the scans above and below the fovea, the reduction in OPL area was significant at each visit (
p
< 0.0001). In comparison with healthy control subjects, OPL area values in patients with TB SLC were significantly lower at the month-3 (6116 ± 1441 versus 7136 ± 2539;
p
= 0.04) and the 6-month visit (5487 ± 1461 versus 7136 ± 2539;
p
< 0.001). The atrophied OPL at month 6 has been referred to as the “middle limiting membrane” (MLM). Subjects with TB SLC may develop progressive atrophy of the OPL resulting in formation of MLM, which is seen as a hyper-reflective line replacing the OPL. The analysis of longitudinal changes in the OPL may be useful in predicting anatomical and functional outcomes in these patients.</description><subject>692/308/53</subject><subject>692/699/3161</subject><subject>Adult</subject><subject>Atrophy</subject><subject>Automation</subject><subject>Choroid - physiopathology</subject><subject>Choroiditis</subject><subject>Choroiditis - physiopathology</subject><subject>Evaluation Studies as Topic</subject><subject>Eye</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Membranes - physiopathology</subject><subject>multidisciplinary</subject><subject>Patients</subject><subject>Quantitative analysis</subject><subject>Retina</subject><subject>Retina - physiopathology</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Tuberculosis, Ocular - physiopathology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9Us1uFiEUnRiNbWpfwIUhceNmlAGGgY2Jafxp0sSFuiYMc5mPT2aYAtPmexpfVdqptXUhCYHce87hcu-pqpcNfttgKt4l1rRS1Jg0ZQvJavmkOiaYtTWhhDx9cD-qTlPa47JaIlkjn1dHlImOkoYdV7--weRqveYw6QwDulz1nF3W2V0B0rP2h-QSChblHaDJDYMH5N3ksptHNMHURz0DcjPKaw_RrF5HlCAubnRzWFPt3U9AZhdicEMhJbSmG2a6hiXXKazRAApLdkZ7ZMIOIswlUqoJY9TL7vCiema1T3B6d55UPz59_H72pb74-vn87MNFbVqGcy2h09a0ltqm4xr3HWECa-gEp5gYKpgFXNpEWkNw09tWUMwNx4A1x8RSoCfV-aY7BL1XS3STjgcVtFO3gRBHpWMp04PipmOyE6y3AjPLe90xNnBiZU8HpqUpWu83rWXtJxgMzDlq_0j0cWZ2OzWGKyV4mYtsisCbO4EYLldIWU0uGfC-9Lo0VRGOu1ZIKkiBvv4Hui9NLXPbUFhQLtuCIhvKxJBSBHtfTIPVjZ3UZidV7KRu7aRkIb16-I17yh_zFADdAKmk5hHi37f_I_sbelDaMw</recordid><startdate>20211206</startdate><enddate>20211206</enddate><creator>Agarwal, Aniruddha</creator><creator>Kalra, Gagan</creator><creator>Agrawal, Rupesh</creator><creator>Bansal, Reema</creator><creator>Gupta, Vishali</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20211206</creationdate><title>Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography</title><author>Agarwal, Aniruddha ; Kalra, Gagan ; Agrawal, Rupesh ; Bansal, Reema ; Gupta, Vishali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-9e7afc5f3f176a0b72480ae786302c384fe002825c201bf58306c60e0a602f3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/308/53</topic><topic>692/699/3161</topic><topic>Adult</topic><topic>Atrophy</topic><topic>Automation</topic><topic>Choroid - physiopathology</topic><topic>Choroiditis</topic><topic>Choroiditis - physiopathology</topic><topic>Evaluation Studies as Topic</topic><topic>Eye</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Membranes - physiopathology</topic><topic>multidisciplinary</topic><topic>Patients</topic><topic>Quantitative analysis</topic><topic>Retina</topic><topic>Retina - physiopathology</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Tuberculosis, Ocular - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, Aniruddha</creatorcontrib><creatorcontrib>Kalra, Gagan</creatorcontrib><creatorcontrib>Agrawal, Rupesh</creatorcontrib><creatorcontrib>Bansal, Reema</creatorcontrib><creatorcontrib>Gupta, Vishali</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, Aniruddha</au><au>Kalra, Gagan</au><au>Agrawal, Rupesh</au><au>Bansal, Reema</au><au>Gupta, Vishali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-12-06</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>23493</spage><epage>23493</epage><pages>23493-23493</pages><artnum>23493</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three OCT scans were chosen—one passing through the center of the fovea, one line above, and one line below. After random indexing to anonymize the images, they were pre-processed and fed into an automated pipeline to identify, crop, and measure the area of the OPL in the line scan. Longitudinal comparisons of OPL within the patient group were performed. The study included 32 eyes (16 patients; 11 males; mean age: 32.9 ± 7.8 years) with TB SLC. Twenty-eight eyes (14 subjects; 10 males: mean age: 31.1 ± 6.2 years) of healthy control subjects (age- and gender-matched) were also selected. The area of OPL was significantly different between the baseline and month 6 visit (6288 ± 1803 versus 5487 ± 1461;
p
= 0.0002) at the central scan passing through the fovea. For the scans above and below the fovea, the reduction in OPL area was significant at each visit (
p
< 0.0001). In comparison with healthy control subjects, OPL area values in patients with TB SLC were significantly lower at the month-3 (6116 ± 1441 versus 7136 ± 2539;
p
= 0.04) and the 6-month visit (5487 ± 1461 versus 7136 ± 2539;
p
< 0.001). The atrophied OPL at month 6 has been referred to as the “middle limiting membrane” (MLM). Subjects with TB SLC may develop progressive atrophy of the OPL resulting in formation of MLM, which is seen as a hyper-reflective line replacing the OPL. The analysis of longitudinal changes in the OPL may be useful in predicting anatomical and functional outcomes in these patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34873214</pmid><doi>10.1038/s41598-021-02894-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/53 692/699/3161 Adult Atrophy Automation Choroid - physiopathology Choroiditis Choroiditis - physiopathology Evaluation Studies as Topic Eye Female Humanities and Social Sciences Humans Male Membranes - physiopathology multidisciplinary Patients Quantitative analysis Retina Retina - physiopathology Retrospective Studies Science Science (multidisciplinary) Tomography Tomography, Optical Coherence - methods Tuberculosis, Ocular - physiopathology |
| title | Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography |
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