The SPFH Protein Superfamily in Fungi: Impact on Mitochondrial Function and Implications in Virulence

Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling...

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Bibliographic Details
Published in:Microorganisms (Basel) 2021-11, Vol.9 (11), p.2287
Main Authors: Heredia, Marienela Y., Rauceo, Jason M.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antifungal agents
Apoptosis
Drug development
Drug resistance
Filamentation
Fungi
Fungicides
Genes
Genomes
Ion transport
Localization
Mammals
Mass spectrometry
Mechanotransduction
Membrane proteins
Mitochondria
Molecular weight
Nematodes
Oxidative stress
Parasites
Physiology
Plasma
Prohibitin
Proteins
Review
Scientific imaging
Signaling
SPFH
stomatin
Virulence
Yeast
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Summary:Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms. Mammalian SPFH proteins are primarily associated with mitochondrial functions but also coordinate key processes such as ion transport, signaling, and mechanosensation. In addition, SPFH proteins are required for virulence in parasites. While mitochondrial functions of SPFH proteins are conserved in fungi, recent evidence has uncovered additional roles for SPFH proteins in filamentation and stress signaling. Inhibitors that target SPFH proteins have been successfully used in cancer and inflammation treatment. Thus, SPFH proteins may serve as a potential target for novel antifungal drug development. This review article surveys SPFH function in various fungal species with a special focus on the most common human fungal pathogen, Candida albicans.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9112287