Epigenetics and Helicobacter pylori

Epigenetics regulates gene expression, cell type development during differentiation, and the cell response to environmental stimuli. To survive, bacteria need to evade the host immune response. Bacteria, including ( ), reach this target epigenetically, altering the chromatin of the host cells, in ad...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (3), p.1759
Main Authors: Capparelli, Rosanna, Iannelli, Domenico
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial infections
cancer
Cell differentiation
Cell division
Chromatin
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA methylation
DNA Methylation - genetics
Environmental effects
Epigenesis, Genetic
Epigenetics
Gastric cancer
Gastric mucosa
Gene expression
Gene Expression Regulation, Bacterial
Gene silencing
Genes
Genetic diversity
Genetic Markers
Genomes
Helicobacter Infections - genetics
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori and Epstein-Barr virus co-infection
Heredity
Humans
Immune response
Infections
Microbial Viability - genetics
Mutation
Pathogens
Proteins
Recombination
Review
Success
Tuberculosis
Tumor suppressor genes
Tumors
Ulcers
Virulence
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Summary:Epigenetics regulates gene expression, cell type development during differentiation, and the cell response to environmental stimuli. To survive, bacteria need to evade the host immune response. Bacteria, including ( ), reach this target epigenetically, altering the chromatin of the host cells, in addition to several more approaches, such as DNA mutation and recombination. This review shows that prevalently silences the genes of the human gastric mucosa by DNA methylation. Epigenetics includes different mechanisms. However, DNA methylation persists after DNA replication and therefore is frequently associated with the inheritance of repressed genes. Chromatin modification can be transmitted to daughter cells leading to heritable changes in gene expression. Aberrant epigenetic alteration of the gastric mucosa DNA remains the principal cause of gastric cancer. Numerous methylated genes have been found in cancer as well as in precancerous lesions of -infected patients. These methylated genes inactivate tumor-suppressor genes. It is time for us to complain about our genetic and epigenetic makeups for our diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23031759