Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes

Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with o...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-11, Vol.26 (23), p.7221
Main Authors: Fu, Bo, Escorihuela, Jorge, Han, Jianlin, Fustero, Santos, Barrio, Pablo, Sodeoka, Mikiko, Kawamura, Shintaro, Sorochinsky, Alexander, Soloshonok, Vadim
Format: Article
Language:English
Subjects:
Agrochemicals
Alkenes
Alkynes
Carbon
Catalysis
Chemistry
Chloride
cyanotrifluoromethylation
difunctionalization
Fluorine
halotrifluoromethylation
Organic chemistry
Pharmaceutical industry
Reagents
Review
Solvents
synthetic methods
Temperature
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Summary:Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26237221