Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children

In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (...

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Bibliographic Details
Published in:Nutrients 2018-05, Vol.10 (6), p.680
Main Authors: Brett, Neil R, Lavery, Paula, Agellon, Sherry, Vanstone, Catherine A, Goruk, Susan, Field, Catherine J, Weiler, Hope A
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
25-Hydroxyvitamin D 2 - blood
Biomarkers - blood
Calcifediol - blood
Child
Child Nutritional Physiological Phenomena
Child, Preschool
Children
Cross-Sectional Studies
Female
Follow-Up Studies
Food, Fortified
Fortified foods
Humans
Illnesses
immune function
Immune response
Immune System - immunology
Immune System - physiopathology
Infant
Inflammation Mediators - blood
Influenza, Human - immunology
Influenza, Human - prevention & control
Interleukin 6
Leukocytes (mononuclear)
Lymphocytes
Male
Nutrition Assessment
Nutritional Status
Peripheral blood
Quebec
Respiratory Tract Infections - immunology
Respiratory Tract Infections - prevention & control
Seasons
Tumor necrosis factor-α
Urban Health
Vitamin D
Vitamin D - administration & dosage
Vitamin D - therapeutic use
Vitamin D Deficiency - blood
Vitamin D Deficiency - immunology
Vitamin D Deficiency - physiopathology
Vitamin D Deficiency - prevention & control
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Summary:In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years ( = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old ( = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher ( < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu10060680