The Yin/Yang Balance of Communication between Sensory Neurons and Macrophages in Traumatic Peripheral Neuropathic Pain

Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating macrophages proliferate and initiate a cross-talk with the sensory neurons, at the level of peripheral nerves and...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (20), p.12389
Main Authors: Gheorghe, Roxana-Olimpia, Grosu, Andreea Violeta, Bica-Popi, Melania, Ristoiu, Violeta
Format: Article
Language:English
Subjects:
chemokines
Connective tissue
Crosstalk
cytokines
Genotype & phenotype
Injuries
Injury prevention
Lesions
Macrophages
miRNA
Nervous system
Neurons
nociceptors
Pain
Pain perception
Peripheral nerves
Peripheral nervous system
Population
Review
Sensory neurons
traumatic neuropathic pain
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Summary:Traumatic peripheral neuropathic pain is a complex syndrome caused by a primary lesion or dysfunction of the peripheral nervous system. Secondary to the lesion, resident or infiltrating macrophages proliferate and initiate a cross-talk with the sensory neurons, at the level of peripheral nerves and sensory ganglia. The neuron–macrophage interaction, which starts very early after the lesion, is very important for promoting pain development and for initiating changes that will facilitate the chronicization of pain, but it also has the potential to facilitate the resolution of injury-induced changes and, consequently, promote the reduction of pain. This review is an overview of the unique characteristics of nerve-associated macrophages in the peripheral nerves and sensory ganglia and of the molecules and signaling pathways involved in the neuro-immune cross-talk after a traumatic lesion, with the final aim of better understanding how the balance between pro- and anti-nociceptive dialogue between neurons and macrophages may be modulated for new therapeutic approaches.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012389