SUMOylation-Mediated Response to Mitochondrial Stress

Mitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like modifier (SUMO) and its specific proteases (S...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (16), p.5657
Main Authors: He, Jianli, Cheng, Jinke, Wang, Tianshi
Format: Article
Language:English
Subjects:
Adaptation
Animals
Apoptosis
Biosynthesis
Caloric Restriction
Calories
Dehydrogenases
Enzymes
Fatty acids
Glucose
Homeostasis
Humans
Hypoxia
Kinases
Metabolism
Mitochondria
Mitochondria - metabolism
mitochondrion
Morphology
Organelle Biogenesis
Oxidation
Oxidative stress
Proteins
Respiration
Review
Senescence
SENPs
stress response
Stress, Physiological
SUMO
SUMO protein
SUMOylation
Ubiquitin
Unfolded Protein Response
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Summary:Mitochondrial stress is considered as a factor that reprograms the mitochondrial biogenesis and metabolism. As known, SUMOylation occurs through a series of stress-induced biochemical reactions. During the process of SUMOylation, the small ubiquitin-like modifier (SUMO) and its specific proteases (SENPs) are key signal molecules. Furthermore, they are considered as novel mitochondrial stress sensors that respond to the signals produced by various stresses. The responses are critical for mitochondrial homeostasis. The scope of this review is to provide an overview of the function of SUMOylation in the mitochondrial stress response, to delineate a SUMOylation-involved signal network diagram, and to highlight a number of key questions that remain answered.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21165657