Review of cancer cell volatile organic compounds: their metabolism and evolution

Cancer is ranked as the top cause of premature mortality. Volatile organic compounds (VOCs) are produced from catalytic peroxidation by reactive oxygen species (ROS) and have become a highly attractive non-invasive cancer screening approach. For future clinical applications, however, the correlation...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2025-01, Vol.11, p.1499104
Main Authors: Furuhashi, Takeshi, Toda, Kanako, Weckwerth, Wolfram
Format: Article
Language:English
Subjects:
cancer evolution
cellular metabolism
lipid peroxidation
Molecular Biosciences
multifunctional enzyme
ROS
VOCs (volatile organic compounds)
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Summary:Cancer is ranked as the top cause of premature mortality. Volatile organic compounds (VOCs) are produced from catalytic peroxidation by reactive oxygen species (ROS) and have become a highly attractive non-invasive cancer screening approach. For future clinical applications, however, the correlation between cancer hallmarks and cancer-specific VOCs requires further study. This review discusses and compares cellular metabolism, signal transduction as well as mitochondrial metabolite translocation in view of cancer evolution and the basic biology of VOCs production. Certain cancerous characteristics as well as the origin of the ROS removal system date back to procaryotes and early eukaryotes and share commonalities with non-cancerous proliferative cells. This calls for future studies on metabolic cross talks and regulation of the VOCs production pathway.
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2024.1499104