TCP post-radioembolization and TCP post-EBRT in HCC are similar and can be predicted using the in vitro radiosensitivity

Background Tumor equivalent uniform dose (EUD) is proposed as a predictor of patient outcome after liver radioembolization (RE) of hepatocellular carcinoma (HCC) and can be evaluated with 90 Y-TOF-PET. The aim is to evaluate the correlation between PET-based tumors EUD and the clinical response eval...

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Bibliographic Details
Published in:EJNMMI research 2022-07, Vol.12 (1), p.40-40, Article 40
Main Authors: d’Abadie, Philippe, Walrand, Stephan, Hesse, Michel, Borbath, Ivan, Lhommel, Renaud, Jamar, François
Format: Article
Language:English
Subjects:
Acetate
Cardiac Imaging
EUD
Evaluation
FDG
HCC
Imaging
Liver cancer
Medicine
Medicine & Public Health
Metabolism
Nuclear Medicine
Oncology
Original Research
Orthopedics
PET
Radiation therapy
Radiation tolerance
Radiology
TCP
Tumors
Yttrium isotopes
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Summary:Background Tumor equivalent uniform dose (EUD) is proposed as a predictor of patient outcome after liver radioembolization (RE) of hepatocellular carcinoma (HCC) and can be evaluated with 90 Y-TOF-PET. The aim is to evaluate the correlation between PET-based tumors EUD and the clinical response evaluated with dual molecular tracer ( 11 C-acetate and 18 F-FDG) PET/CT post-RE. Methods 34 HCC tumors in 22 patients were prospectively evaluated. The metabolic response was characterized by the total lesion metabolism variation (ΔTLM) between baseline and follow-up. This response allowed to compute a tumor control probability (TCP) as a function of the tumor EUD. Results The absorbed dose response correlation was highly significant ( R  = 0.72, P  
ISSN:2191-219X
2191-219X
DOI:10.1186/s13550-022-00911-0